Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies
Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/34661/ http://umpir.ump.edu.my/id/eprint/34661/1/Colorectal%20cancer_A%20review%20of%20carcinogenesis%2C%20global%20epidemiology%2C%20current%20challenges.pdf |
| _version_ | 1848824567506665472 |
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| author | Hossain, Md. Sanower Hidayah, Karuniawati Jairoun, Ammar Abdulrahman Urbi, Zannat Ooi, Der Jiun John, Akbar Lim, Ya Chee K. M., Kaderi Kibria A. K. M., Mohiuddin Ming, Long Chiau Goh, Khang Wen Hadi, Muhammad Abdul |
| author_facet | Hossain, Md. Sanower Hidayah, Karuniawati Jairoun, Ammar Abdulrahman Urbi, Zannat Ooi, Der Jiun John, Akbar Lim, Ya Chee K. M., Kaderi Kibria A. K. M., Mohiuddin Ming, Long Chiau Goh, Khang Wen Hadi, Muhammad Abdul |
| author_sort | Hossain, Md. Sanower |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries too. CRC detected early is entirely curable by surgery and subsequent medications. However, the recurrence rate is high, and cancer drug resistance increases the treatment failure rate. Access to early diagnosis and treatment of CRC for survival is somewhat possible in developed countries. However, these facilities are rarely available in developing countries. Highlighting the current status of CRC, its development, risk factors, and management is crucial in creating public awareness. Therefore, in this review, we have comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of CRC. Additionally, there is a brief discussion on the CRC development pathways and recommendations for preventing and treating CRC. |
| first_indexed | 2025-11-15T03:15:05Z |
| format | Article |
| id | ump-34661 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:15:05Z |
| publishDate | 2022 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-346612022-11-10T01:23:21Z http://umpir.ump.edu.my/id/eprint/34661/ Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies Hossain, Md. Sanower Hidayah, Karuniawati Jairoun, Ammar Abdulrahman Urbi, Zannat Ooi, Der Jiun John, Akbar Lim, Ya Chee K. M., Kaderi Kibria A. K. M., Mohiuddin Ming, Long Chiau Goh, Khang Wen Hadi, Muhammad Abdul HD Industries. Land use. Labor Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology (General) Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries too. CRC detected early is entirely curable by surgery and subsequent medications. However, the recurrence rate is high, and cancer drug resistance increases the treatment failure rate. Access to early diagnosis and treatment of CRC for survival is somewhat possible in developed countries. However, these facilities are rarely available in developing countries. Highlighting the current status of CRC, its development, risk factors, and management is crucial in creating public awareness. Therefore, in this review, we have comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of CRC. Additionally, there is a brief discussion on the CRC development pathways and recommendations for preventing and treating CRC. MDPI 2022-04-01 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/34661/1/Colorectal%20cancer_A%20review%20of%20carcinogenesis%2C%20global%20epidemiology%2C%20current%20challenges.pdf Hossain, Md. Sanower and Hidayah, Karuniawati and Jairoun, Ammar Abdulrahman and Urbi, Zannat and Ooi, Der Jiun and John, Akbar and Lim, Ya Chee and K. M., Kaderi Kibria and A. K. M., Mohiuddin and Ming, Long Chiau and Goh, Khang Wen and Hadi, Muhammad Abdul (2022) Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers, 14 (7). pp. 1-25. ISSN 2072-6694. (Published) https://doi.org/10.3390/cancers14071732 https://doi.org/10.3390/cancers14071732 |
| spellingShingle | HD Industries. Land use. Labor Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology (General) Hossain, Md. Sanower Hidayah, Karuniawati Jairoun, Ammar Abdulrahman Urbi, Zannat Ooi, Der Jiun John, Akbar Lim, Ya Chee K. M., Kaderi Kibria A. K. M., Mohiuddin Ming, Long Chiau Goh, Khang Wen Hadi, Muhammad Abdul Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title | Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title_full | Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title_fullStr | Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title_full_unstemmed | Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title_short | Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| title_sort | colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies |
| topic | HD Industries. Land use. Labor Q Science (General) RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology (General) |
| url | http://umpir.ump.edu.my/id/eprint/34661/ http://umpir.ump.edu.my/id/eprint/34661/ http://umpir.ump.edu.my/id/eprint/34661/ http://umpir.ump.edu.my/id/eprint/34661/1/Colorectal%20cancer_A%20review%20of%20carcinogenesis%2C%20global%20epidemiology%2C%20current%20challenges.pdf |