A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer
Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of...
| Main Authors: | Kelvin Wong, Khai Voon, Ahmad Mahfuz, Gazali, Normaiza, Zamri, Kamal, Rullah, Mohd Fadhlizil Fasihi, Mohd Aluwi |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing Co Pte Ltd
2022
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/34459/ http://umpir.ump.edu.my/id/eprint/34459/1/A%20Mini-Review%20on%20the%20Insight%20into%20the%20Effect%20of%20Natural.pdf |
Similar Items
A Potential Effect of Cordycepin on the Feedback between Polyadenylation and PI3K/Akt/mTOR Signalling
by: Lawrence, Steven
Published: (2023)
by: Lawrence, Steven
Published: (2023)
PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
by: Chen, J., et al.
Published: (2015)
by: Chen, J., et al.
Published: (2015)
Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023)
by: Alzahrani, Badr, et al.
Published: (2023)
Structure-based virtual screening towards the discovery of usnic acid derivatives as novel mTOR inhibitor to treat breast cancer
by: Wong, Kelvin Khai Voon, et al.
Published: (2022)
by: Wong, Kelvin Khai Voon, et al.
Published: (2022)
Sodium alginate encapsulated iron oxide decorated with thymoquinone nanocomposite induces apoptosis in human breast cancer cells via PI3K-Akt-mTOR pathway
by: Alzahrani, Badr, et al.
Published: (2023)
by: Alzahrani, Badr, et al.
Published: (2023)
Nanocomposites of iron oxide, sodium alginate, and eugenol induce apoptosis via PI3K/Akt/mTOR signaling in Hep3 cells and in vivo hepatotoxicity in the zebrafish model
by: Elderdery, Abozer Y., et al.
Published: (2024)
by: Elderdery, Abozer Y., et al.
Published: (2024)
γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen, K., et al.
Published: (2014)
by: Siveen, K., et al.
Published: (2014)
Enhanced apoptotic activity of Pluronic F127 polymer-encapsulated chlorogenic acid nanoparticles through the PI3K/Akt/mTOR signaling pathway in liver cancer cells and in vivo toxicity studies in zebrafish
by: Alanazi, Fehaid, et al.
Published: (2023)
by: Alanazi, Fehaid, et al.
Published: (2023)
Induction of apoptosis via JNK and AKT/mTOR signaling pathways by Alternanthera sessilis (L.) R.Br. ex DC. in colorectal cancer in vitro and in vivo
by: Sivapragasam, Gothai
Published: (2019)
by: Sivapragasam, Gothai
Published: (2019)
Translational control : mTOR signalling and the use of next-generation sequencing methods
by: Jackson, Thomas John
Published: (2013)
by: Jackson, Thomas John
Published: (2013)
Molecular regulation of jnk in tnf-α-stimulated human hepatocarcinoma (hepg2) cells via the mtor/akt pathway
by: Ng, Di Lin
Published: (2011)
by: Ng, Di Lin
Published: (2011)
Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
by: Azimzadeh, Mansour, et al.
Published: (2024)
by: Azimzadeh, Mansour, et al.
Published: (2024)
GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
by: Carlessi, Rodrigo, et al.
Published: (2017)
by: Carlessi, Rodrigo, et al.
Published: (2017)
siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
by: Salama, Mohamed M., et al.
Published: (2019)
by: Salama, Mohamed M., et al.
Published: (2019)
Elucidating the effects of mTOR inhibitors from Malaysian natural products on tuberous sclerosis complex cell line
by: Zulkipli, Ninie Nadia
Published: (2022)
by: Zulkipli, Ninie Nadia
Published: (2022)
Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
by: Roney, Miah, et al.
Published: (2024)
by: Roney, Miah, et al.
Published: (2024)
Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway
by: Khaled bin Break, Mohammed, et al.
Published: (2018)
by: Khaled bin Break, Mohammed, et al.
Published: (2018)
Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells
by: Pandurangan, Ashok Kumar, et al.
Published: (2018)
by: Pandurangan, Ashok Kumar, et al.
Published: (2018)
Diabetic wound healing of aloe vera major phytoconstituents through TGF-b1 suppression via in-silico docking, molecular dynamic simulation and pharmacokinetic studies
by: Roney, Miah, et al.
Published: (2023)
by: Roney, Miah, et al.
Published: (2023)
Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)
An in-silico approach to evaluate bioactive molecules of aloe vera leaf extracts in inhibiting the glycogen synthase kinase-3β (GSK3-β) protein for faster diabetic wound healing potential
by: Roney, Miah, et al.
Published: (2024)
by: Roney, Miah, et al.
Published: (2024)
Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
by: Singh, S., et al.
Published: (2015)
by: Singh, S., et al.
Published: (2015)
Semi-synthesis of novel cardamonin analogues and identification of a highly active Cu(II)-cardamonin complex that inhibits migration and induces apoptosis via inhibition of mTOR expression
by: Bin Break, Mohammed Khaled Ali
Published: (2018)
by: Bin Break, Mohammed Khaled Ali
Published: (2018)
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
by: Geyer, Felipe C., et al.
Published: (2018)
by: Geyer, Felipe C., et al.
Published: (2018)
An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
by: Smit, L., et al.
Published: (2015)
by: Smit, L., et al.
Published: (2015)
Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lines
by: Roney, Miah, et al.
Published: (2025)
by: Roney, Miah, et al.
Published: (2025)
Inhibitory effect of Sinapic acid derivatives targeting structural and non-structural proteins of dengue virus serotype 2 An in-silico assessment
by: Roney, Miah, et al.
Published: (2023)
by: Roney, Miah, et al.
Published: (2023)
Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production
by: Rullah, Kamal, et al.
Published: (2019)
by: Rullah, Kamal, et al.
Published: (2019)
Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway
by: Chen, Jichao, et al.
Published: (2017)
by: Chen, Jichao, et al.
Published: (2017)
Vitamin D and Stimulates the PI3K-AKT signaling pathway in insulin resistant SK-N-SH neuronal cells
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
Pharmacophore-based molecular docking and in-silico study of novel usnic acid derivatives as avian influenza A (H7N9) inhibitor
by: Roney, Miah, et al.
Published: (2022)
by: Roney, Miah, et al.
Published: (2022)
Pharmacophore-based molecular docking of usnic acid derivatives to discover anti-viral drugs against influenza A virus
by: Roney, Miah, et al.
Published: (2023)
by: Roney, Miah, et al.
Published: (2023)
Anti-amoebic properties of carbonyl thiourea derivatives
by: Ibrahim, Maizatul Akma, et al.
Published: (2014)
by: Ibrahim, Maizatul Akma, et al.
Published: (2014)
Antimicrobial assay of trimethoxy carbonyl thiourea complexes
by: Umme Najehah, Ahmad
Published: (2013)
by: Umme Najehah, Ahmad
Published: (2013)
Mefenamic acid inhibit transforming growth factor-beta type-1: Repurposing anti-inflammatory drugs in wound healing using in-silico approaches
by: Roney, Miah, et al.
Published: (2023)
by: Roney, Miah, et al.
Published: (2023)
Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma
by: Huang, B., et al.
Published: (2016)
by: Huang, B., et al.
Published: (2016)
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
by: Falasca, Marco, et al.
Published: (2010)
by: Falasca, Marco, et al.
Published: (2010)
Vitamins D and E stimulate the PI3K-AKT signalling pathway in insulin-resistant SK-N-SH neuronal cells
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
Comparison of the expression of PI3K/AKT pathway components in type 2 diabetic and non- diabetic human volunteers ex vivo
by: Khorami, Somayeh Alsadat Hosseini
Published: (2018)
by: Khorami, Somayeh Alsadat Hosseini
Published: (2018)
Time-resolved infrared studies of metal carbonyl complexes
by: Wu, Lingjun
Published: (2020)
by: Wu, Lingjun
Published: (2020)
Similar Items
-
A Potential Effect of Cordycepin on the Feedback between Polyadenylation and PI3K/Akt/mTOR Signalling
by: Lawrence, Steven
Published: (2023) -
PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
by: Chen, J., et al.
Published: (2015) -
Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023) -
Structure-based virtual screening towards the discovery of usnic acid derivatives as novel mTOR inhibitor to treat breast cancer
by: Wong, Kelvin Khai Voon, et al.
Published: (2022) -
Sodium alginate encapsulated iron oxide decorated with thymoquinone nanocomposite induces apoptosis in human breast cancer cells via PI3K-Akt-mTOR pathway
by: Alzahrani, Badr, et al.
Published: (2023)