The study of myocardial ischemia-reperfusion treatment through computational modelling
Reperfusion of the blood flow to ischemic myocardium is the standard treatment for patients suffering myocardial infarction. However, the reperfusion itself can also induce myocardial injury, in which the actual mechanism and its risk factors remain unclear. This work aims to study the mechanism of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/33808/ http://umpir.ump.edu.my/id/eprint/33808/1/The%20study%20of%20myocardial%20ischemia.pdf |
| _version_ | 1848824350361255936 |
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| author | Wan Naimah, Wan Ab Naim Mohd Jamil Mohamed, Mokhtarudin Bee, Ting Chan Einly, Lim Azam, Ahmad Bakir Nik Abdullah, Nik Mohamed |
| author_facet | Wan Naimah, Wan Ab Naim Mohd Jamil Mohamed, Mokhtarudin Bee, Ting Chan Einly, Lim Azam, Ahmad Bakir Nik Abdullah, Nik Mohamed |
| author_sort | Wan Naimah, Wan Ab Naim |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Reperfusion of the blood flow to ischemic myocardium is the standard treatment for patients suffering myocardial infarction. However, the reperfusion itself can also induce myocardial injury, in which the actual mechanism and its risk factors remain unclear. This work aims to study the mechanism of ischemia–reperfusion treatment using a three-dimensional (3D) oxygen diffusion model. An electrical model is then coupled to an oxygen model to identify the possible region of myocardial damage. Our findings show that the value of oxygen exceeds its optimum (>1.0) at the ischemic area during early reperfusion period. This complication was exacerbated in a longer ischemic period. While a longer reperfusion time causes a continuous excessive oxygen supply to the ischemic area throughout the reperfusion time. This work also suggests the use of less than 0.8 of initial oxygen concentration in the reperfusion treatment to prevent undesired upsurge at the early reperfusion period and further myocardial injury. We also found the region at risk for myocardial injury is confined in the ischemic vicinity revealed by its electrical conductivity impairment. Although there is a risk that reperfusion leads to myocardial injury for excessive oxygen accumulation, the reperfusion treatment is helpful in reducing the infarct size. |
| first_indexed | 2025-11-15T03:11:38Z |
| format | Article |
| id | ump-33808 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:11:38Z |
| publishDate | 2021 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-338082022-04-20T08:04:39Z http://umpir.ump.edu.my/id/eprint/33808/ The study of myocardial ischemia-reperfusion treatment through computational modelling Wan Naimah, Wan Ab Naim Mohd Jamil Mohamed, Mokhtarudin Bee, Ting Chan Einly, Lim Azam, Ahmad Bakir Nik Abdullah, Nik Mohamed RD Surgery TJ Mechanical engineering and machinery Reperfusion of the blood flow to ischemic myocardium is the standard treatment for patients suffering myocardial infarction. However, the reperfusion itself can also induce myocardial injury, in which the actual mechanism and its risk factors remain unclear. This work aims to study the mechanism of ischemia–reperfusion treatment using a three-dimensional (3D) oxygen diffusion model. An electrical model is then coupled to an oxygen model to identify the possible region of myocardial damage. Our findings show that the value of oxygen exceeds its optimum (>1.0) at the ischemic area during early reperfusion period. This complication was exacerbated in a longer ischemic period. While a longer reperfusion time causes a continuous excessive oxygen supply to the ischemic area throughout the reperfusion time. This work also suggests the use of less than 0.8 of initial oxygen concentration in the reperfusion treatment to prevent undesired upsurge at the early reperfusion period and further myocardial injury. We also found the region at risk for myocardial injury is confined in the ischemic vicinity revealed by its electrical conductivity impairment. Although there is a risk that reperfusion leads to myocardial injury for excessive oxygen accumulation, the reperfusion treatment is helpful in reducing the infarct size. Elsevier Ltd 2021 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/33808/1/The%20study%20of%20myocardial%20ischemia.pdf Wan Naimah, Wan Ab Naim and Mohd Jamil Mohamed, Mokhtarudin and Bee, Ting Chan and Einly, Lim and Azam, Ahmad Bakir and Nik Abdullah, Nik Mohamed (2021) The study of myocardial ischemia-reperfusion treatment through computational modelling. Journal of Theoretical Biology, 509 (110527). pp. 1-11. ISSN 0022-5193. (Published) https://doi.org/10.1016/j.jtbi.2020.110527 https://doi.org/10.1016/j.jtbi.2020.110527 |
| spellingShingle | RD Surgery TJ Mechanical engineering and machinery Wan Naimah, Wan Ab Naim Mohd Jamil Mohamed, Mokhtarudin Bee, Ting Chan Einly, Lim Azam, Ahmad Bakir Nik Abdullah, Nik Mohamed The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title | The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title_full | The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title_fullStr | The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title_full_unstemmed | The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title_short | The study of myocardial ischemia-reperfusion treatment through computational modelling |
| title_sort | study of myocardial ischemia-reperfusion treatment through computational modelling |
| topic | RD Surgery TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/33808/ http://umpir.ump.edu.my/id/eprint/33808/ http://umpir.ump.edu.my/id/eprint/33808/ http://umpir.ump.edu.my/id/eprint/33808/1/The%20study%20of%20myocardial%20ischemia.pdf |