Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexa...
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| Format: | Article |
| Language: | English |
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American Chemical Society
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/31392/ http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf |
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| author | Pal, Arpita Roy, Sudeep Kumar, Akhil Mahmood, Syed Nasrin, Khodapanah Thomas, Sabu Agatemor, Christian Ghosal, Kajal |
| author_facet | Pal, Arpita Roy, Sudeep Kumar, Akhil Mahmood, Syed Nasrin, Khodapanah Thomas, Sabu Agatemor, Christian Ghosal, Kajal |
| author_sort | Pal, Arpita |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2. |
| first_indexed | 2025-11-15T03:02:13Z |
| format | Article |
| id | ump-31392 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:02:13Z |
| publishDate | 2020 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-313922021-07-09T02:27:05Z http://umpir.ump.edu.my/id/eprint/31392/ Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes Pal, Arpita Roy, Sudeep Kumar, Akhil Mahmood, Syed Nasrin, Khodapanah Thomas, Sabu Agatemor, Christian Ghosal, Kajal TP Chemical technology This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2. American Chemical Society 2020-08-18 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf Pal, Arpita and Roy, Sudeep and Kumar, Akhil and Mahmood, Syed and Nasrin, Khodapanah and Thomas, Sabu and Agatemor, Christian and Ghosal, Kajal (2020) Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes. ACS Omega, 5 (32). pp. 19968-19977. ISSN 2470-1343. (Published) https://doi.org/10.1021/acsomega.0c01228 https://doi.org/10.1021/acsomega.0c01228 |
| spellingShingle | TP Chemical technology Pal, Arpita Roy, Sudeep Kumar, Akhil Mahmood, Syed Nasrin, Khodapanah Thomas, Sabu Agatemor, Christian Ghosal, Kajal Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title | Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title_full | Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title_fullStr | Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title_full_unstemmed | Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title_short | Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| title_sort | physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/31392/ http://umpir.ump.edu.my/id/eprint/31392/ http://umpir.ump.edu.my/id/eprint/31392/ http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf |