Advances in biomaterials for hepatic tissue engineering
Liver/hepatocyte regeneration effectively occurs after an in vivo physiological insult and is guided by stimuli from the extracellular matrix (ECM) and signals from neighbouring cells. However, in spite of its ability to regenerate in vivo, long-term propagation of liver cells in culture has been a...
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| Format: | Article |
| Language: | English |
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Elsevier
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/30859/ http://umpir.ump.edu.my/id/eprint/30859/1/Current%20Opinion%20in%20Biomed%20Eng%202020%2013%20190%E2%80%93196_Savneet.pdf |
| _version_ | 1848823618097643520 |
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| author | Kaur, Savneet Tripathi, Dinesh M. Venugopal, Jayarama Reddy Seeram, Ramakrishna |
| author_facet | Kaur, Savneet Tripathi, Dinesh M. Venugopal, Jayarama Reddy Seeram, Ramakrishna |
| author_sort | Kaur, Savneet |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Liver/hepatocyte regeneration effectively occurs after an in vivo physiological insult and is guided by stimuli from the extracellular matrix (ECM) and signals from neighbouring cells. However, in spite of its ability to regenerate in vivo, long-term propagation of liver cells in culture has been a formidable task. This is largely because we still do not have ideal biomaterials that can recapitulate all the essential properties of a native liver ECM ex vivo. Nonetheless, many biomaterials based on natural and synthetic polymers and their blends have been developed in recent years for supporting hepatocyte cultures. Use of decellularized native liver ECM represents one vital step towards liver tissue engineering; however, native ECM has to be appropriately amended with other biomaterials. This critical review presents succinct details about the multitude of biomaterials that have been investigated over the past few years and also propose advanced options for future endeavours in hepatic tissue engineering. |
| first_indexed | 2025-11-15T03:00:00Z |
| format | Article |
| id | ump-30859 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:00:00Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-308592021-09-23T04:33:35Z http://umpir.ump.edu.my/id/eprint/30859/ Advances in biomaterials for hepatic tissue engineering Kaur, Savneet Tripathi, Dinesh M. Venugopal, Jayarama Reddy Seeram, Ramakrishna R Medicine (General) Liver/hepatocyte regeneration effectively occurs after an in vivo physiological insult and is guided by stimuli from the extracellular matrix (ECM) and signals from neighbouring cells. However, in spite of its ability to regenerate in vivo, long-term propagation of liver cells in culture has been a formidable task. This is largely because we still do not have ideal biomaterials that can recapitulate all the essential properties of a native liver ECM ex vivo. Nonetheless, many biomaterials based on natural and synthetic polymers and their blends have been developed in recent years for supporting hepatocyte cultures. Use of decellularized native liver ECM represents one vital step towards liver tissue engineering; however, native ECM has to be appropriately amended with other biomaterials. This critical review presents succinct details about the multitude of biomaterials that have been investigated over the past few years and also propose advanced options for future endeavours in hepatic tissue engineering. Elsevier 2020-03 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30859/1/Current%20Opinion%20in%20Biomed%20Eng%202020%2013%20190%E2%80%93196_Savneet.pdf Kaur, Savneet and Tripathi, Dinesh M. and Venugopal, Jayarama Reddy and Seeram, Ramakrishna (2020) Advances in biomaterials for hepatic tissue engineering. Current Opinion in Biomedical Engineering, 13. pp. 190-196. ISSN 2468-4511. (Published) https://doi.org/10.1016/j.cobme.2020.05.005 https://doi.org/10.1016/j.cobme.2020.05.005 |
| spellingShingle | R Medicine (General) Kaur, Savneet Tripathi, Dinesh M. Venugopal, Jayarama Reddy Seeram, Ramakrishna Advances in biomaterials for hepatic tissue engineering |
| title | Advances in biomaterials for hepatic tissue engineering |
| title_full | Advances in biomaterials for hepatic tissue engineering |
| title_fullStr | Advances in biomaterials for hepatic tissue engineering |
| title_full_unstemmed | Advances in biomaterials for hepatic tissue engineering |
| title_short | Advances in biomaterials for hepatic tissue engineering |
| title_sort | advances in biomaterials for hepatic tissue engineering |
| topic | R Medicine (General) |
| url | http://umpir.ump.edu.my/id/eprint/30859/ http://umpir.ump.edu.my/id/eprint/30859/ http://umpir.ump.edu.my/id/eprint/30859/ http://umpir.ump.edu.my/id/eprint/30859/1/Current%20Opinion%20in%20Biomed%20Eng%202020%2013%20190%E2%80%93196_Savneet.pdf |