Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation
Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for...
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| Format: | Article |
| Language: | English |
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IOP Publishing Ltd
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/30578/ http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf |
| _version_ | 1848823549036331008 |
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| author | E N, Engku Mat Nasir F, Ab Rahman Syarifah, Abd Rahim R Z, Edros N., Anuar |
| author_facet | E N, Engku Mat Nasir F, Ab Rahman Syarifah, Abd Rahim R Z, Edros N., Anuar |
| author_sort | E N, Engku Mat Nasir |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for CBZ concentration of 19.14 mg/ml. Meanwhile, the unimodal with broad PSD were observed at CBZ concentration of 17.01 mg/ml and 17.96 mg/ Crystal characterisation using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) and optical microscopy confirm the solid formed is CBZ-SAC co-crystal Form I with plate-like crystal morphology. |
| first_indexed | 2025-11-15T02:58:54Z |
| format | Article |
| id | ump-30578 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:58:54Z |
| publishDate | 2020 |
| publisher | IOP Publishing Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-305782021-01-27T06:41:20Z http://umpir.ump.edu.my/id/eprint/30578/ Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation E N, Engku Mat Nasir F, Ab Rahman Syarifah, Abd Rahim R Z, Edros N., Anuar TP Chemical technology Abstract. The crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation is presented.The particle size distribution study of CBZ-SAC co-crystals revealed that the multimodal with broad PSD was found for CBZ concentration of 19.14 mg/ml. Meanwhile, the unimodal with broad PSD were observed at CBZ concentration of 17.01 mg/ml and 17.96 mg/ Crystal characterisation using differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier transform infrared (FTIR) and optical microscopy confirm the solid formed is CBZ-SAC co-crystal Form I with plate-like crystal morphology. IOP Publishing Ltd 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf E N, Engku Mat Nasir and F, Ab Rahman and Syarifah, Abd Rahim and R Z, Edros and N., Anuar (2020) Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation. IOP Conf. Series: Materials Science and Engineering, 736 (022109). pp. 1-7. ISSN 1757-899X. (Published) https://iopscience.iop.org/issue/1757-899X/736/2 http://doi:10.1088/1757-899X/736/2/022109 |
| spellingShingle | TP Chemical technology E N, Engku Mat Nasir F, Ab Rahman Syarifah, Abd Rahim R Z, Edros N., Anuar Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title | Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title_full | Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title_fullStr | Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title_full_unstemmed | Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title_short | Crystallisation parameters effect on the particle size distribution (PSD) of carbamazepine-saccharin (CBZ-SAC) co-crystals in batch cooling crystallisation |
| title_sort | crystallisation parameters effect on the particle size distribution (psd) of carbamazepine-saccharin (cbz-sac) co-crystals in batch cooling crystallisation |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/30578/ http://umpir.ump.edu.my/id/eprint/30578/ http://umpir.ump.edu.my/id/eprint/30578/ http://umpir.ump.edu.my/id/eprint/30578/7/Paper%20MKC15002.pdf |