Oral microbiome in children with caries : A systematic review
Oral caries remains a significant public health problem and affects children with early childhood caries (ECC) and severe early childhood caries (S-ECC). However, the mechanisms of these complex multi-species communities are not well understood. This article systematically reviews the studies involv...
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| Format: | Conference or Workshop Item |
| Language: | English English |
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Trans Tech Publications
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/30375/ http://umpir.ump.edu.my/id/eprint/30375/1/15.1%20Oral%20microbiome%20in%20children%20with%20caries-%20A%20systematic%20review.pdf http://umpir.ump.edu.my/id/eprint/30375/7/Oral%20microbiome%20in%20children%20with%20caries-.pdf |
| _version_ | 1848823497067855872 |
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| author | Ramli, Muhammad Zaki Nina Suhaity, Azmi |
| author_facet | Ramli, Muhammad Zaki Nina Suhaity, Azmi |
| author_sort | Ramli, Muhammad Zaki |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Oral caries remains a significant public health problem and affects children with early childhood caries (ECC) and severe early childhood caries (S-ECC). However, the mechanisms of these complex multi-species communities are not well understood. This article systematically reviews the studies involving children with caries to learn the demographics of the subjects, their subjects and types of sample, the methodological approaches undertaken, the main findings, and eventually to make recommendations for future research. A search using a designated search string in the Web of Science resulted in 148 articles. A careful examination of each article based on the inclusion criteria resulted in a final 40 articles. Most of the studies were conducted in the United States and China. The studies involved mostly, but not exclusively, children with primary dentition and were having caries. Different types of subjects were sampled from different racial backgrounds and diseases. Different samples were collected, such as supragingival plaque, saliva and biofilm. Clonal analyses and anaerobic approaches were used to characterise the oral microbiome, including shotgun sequencing, pyrosequencing of 16S rRNA genes, and Pacbio sequencing. Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria were among the phyla commonly reported by the studies. Streptococcus mutans was a key aetiologic agent in the development of caries, besides Veillonella, Prevotella spp. and Lactobacillus spp. Some studies developed models and discussed the applications of oral microbiome in relation to diseases. We recommend further reviews on studies strictly on children with caries and studies involving children only for a better generalisation of the findings. More studies relating oral microbiome with dietary intake and other diseases can also be conducted. |
| first_indexed | 2025-11-15T02:58:04Z |
| format | Conference or Workshop Item |
| id | ump-30375 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T02:58:04Z |
| publishDate | 2020 |
| publisher | Trans Tech Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-303752023-05-17T04:39:32Z http://umpir.ump.edu.my/id/eprint/30375/ Oral microbiome in children with caries : A systematic review Ramli, Muhammad Zaki Nina Suhaity, Azmi RJ Pediatrics RK Dentistry Oral caries remains a significant public health problem and affects children with early childhood caries (ECC) and severe early childhood caries (S-ECC). However, the mechanisms of these complex multi-species communities are not well understood. This article systematically reviews the studies involving children with caries to learn the demographics of the subjects, their subjects and types of sample, the methodological approaches undertaken, the main findings, and eventually to make recommendations for future research. A search using a designated search string in the Web of Science resulted in 148 articles. A careful examination of each article based on the inclusion criteria resulted in a final 40 articles. Most of the studies were conducted in the United States and China. The studies involved mostly, but not exclusively, children with primary dentition and were having caries. Different types of subjects were sampled from different racial backgrounds and diseases. Different samples were collected, such as supragingival plaque, saliva and biofilm. Clonal analyses and anaerobic approaches were used to characterise the oral microbiome, including shotgun sequencing, pyrosequencing of 16S rRNA genes, and Pacbio sequencing. Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria were among the phyla commonly reported by the studies. Streptococcus mutans was a key aetiologic agent in the development of caries, besides Veillonella, Prevotella spp. and Lactobacillus spp. Some studies developed models and discussed the applications of oral microbiome in relation to diseases. We recommend further reviews on studies strictly on children with caries and studies involving children only for a better generalisation of the findings. More studies relating oral microbiome with dietary intake and other diseases can also be conducted. Trans Tech Publications 2020-03 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/30375/1/15.1%20Oral%20microbiome%20in%20children%20with%20caries-%20A%20systematic%20review.pdf pdf en http://umpir.ump.edu.my/id/eprint/30375/7/Oral%20microbiome%20in%20children%20with%20caries-.pdf Ramli, Muhammad Zaki and Nina Suhaity, Azmi (2020) Oral microbiome in children with caries : A systematic review. In: Materials Science Forum; Postgraduate Symposium on Industrial Science and Technology, SISTEC 2019 , 22 - 23 August 2019 , Kuantan, Malaysia. pp. 271-279., 981. ISSN 0255-5476 ISBN 978-303571664-1 (Published) https://doi.org/10.4028/www.scientific.net/MSF.981.271 |
| spellingShingle | RJ Pediatrics RK Dentistry Ramli, Muhammad Zaki Nina Suhaity, Azmi Oral microbiome in children with caries : A systematic review |
| title | Oral microbiome in children with caries : A systematic review |
| title_full | Oral microbiome in children with caries : A systematic review |
| title_fullStr | Oral microbiome in children with caries : A systematic review |
| title_full_unstemmed | Oral microbiome in children with caries : A systematic review |
| title_short | Oral microbiome in children with caries : A systematic review |
| title_sort | oral microbiome in children with caries : a systematic review |
| topic | RJ Pediatrics RK Dentistry |
| url | http://umpir.ump.edu.my/id/eprint/30375/ http://umpir.ump.edu.my/id/eprint/30375/ http://umpir.ump.edu.my/id/eprint/30375/1/15.1%20Oral%20microbiome%20in%20children%20with%20caries-%20A%20systematic%20review.pdf http://umpir.ump.edu.my/id/eprint/30375/7/Oral%20microbiome%20in%20children%20with%20caries-.pdf |