Deciphering the association networks of mycobiome communities among the elderly Danes
Changes of microbial communities have been linked to frailty in elderly, yet the presence of fungal communities and their associations are little understood. This study attemps to identify biologically meaningful gut microbial fungal associations during aging. Faecal samples of 100 Danes of 65 years...
| Main Authors: | , , , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29968/ http://umpir.ump.edu.my/id/eprint/29968/1/CBIO2017%20Poster%20Programme_24%20April.pdf |
| _version_ | 1848823404219596800 |
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| author | Hajar Fauzan, Ahmad Faust, Karoline Castro Mejia, Josue Leonardo Kot, Witold Bechshøft, Rasmus Reitelseder, Søren Holm, Lars Nielsen, Dennis Sandris |
| author_facet | Hajar Fauzan, Ahmad Faust, Karoline Castro Mejia, Josue Leonardo Kot, Witold Bechshøft, Rasmus Reitelseder, Søren Holm, Lars Nielsen, Dennis Sandris |
| author_sort | Hajar Fauzan, Ahmad |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Changes of microbial communities have been linked to frailty in elderly, yet the presence of fungal communities and their associations are little understood. This study attemps to identify biologically meaningful gut microbial fungal associations during aging. Faecal samples of 100 Danes of 65 years or older were collected, and sequenced by high-throughput tag-encoded sequencing of ITS2 gene fragments. The sequences were analysed using QIIME and CoNet to characterise fungal communities, and generate association networks, respectively. HbA1c, identified as the principal node, was grouped into 3 clusters based on glycated glucose levels. The clusters correspond to the phyla Ascomycota, Basidiomycota and Zygomycota, with the genera Penicillium, Candida, and Aspergillus being particularly abundant within each cluster. Interestingly, Bray-Curtis dissimilarity matrices showed significant (P<0.05) variation between clusters. These findings suggest that the presences of specific gut mycobiome members are associated with glycemic behaviours among the healthy individuals of the elderly Danish population. |
| first_indexed | 2025-11-15T02:56:36Z |
| format | Conference or Workshop Item |
| id | ump-29968 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:56:36Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-299682020-11-23T08:18:39Z http://umpir.ump.edu.my/id/eprint/29968/ Deciphering the association networks of mycobiome communities among the elderly Danes Hajar Fauzan, Ahmad Faust, Karoline Castro Mejia, Josue Leonardo Kot, Witold Bechshøft, Rasmus Reitelseder, Søren Holm, Lars Nielsen, Dennis Sandris QR Microbiology RA Public aspects of medicine Changes of microbial communities have been linked to frailty in elderly, yet the presence of fungal communities and their associations are little understood. This study attemps to identify biologically meaningful gut microbial fungal associations during aging. Faecal samples of 100 Danes of 65 years or older were collected, and sequenced by high-throughput tag-encoded sequencing of ITS2 gene fragments. The sequences were analysed using QIIME and CoNet to characterise fungal communities, and generate association networks, respectively. HbA1c, identified as the principal node, was grouped into 3 clusters based on glycated glucose levels. The clusters correspond to the phyla Ascomycota, Basidiomycota and Zygomycota, with the genera Penicillium, Candida, and Aspergillus being particularly abundant within each cluster. Interestingly, Bray-Curtis dissimilarity matrices showed significant (P<0.05) variation between clusters. These findings suggest that the presences of specific gut mycobiome members are associated with glycemic behaviours among the healthy individuals of the elderly Danish population. 2017 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29968/1/CBIO2017%20Poster%20Programme_24%20April.pdf Hajar Fauzan, Ahmad and Faust, Karoline and Castro Mejia, Josue Leonardo and Kot, Witold and Bechshøft, Rasmus and Reitelseder, Søren and Holm, Lars and Nielsen, Dennis Sandris (2017) Deciphering the association networks of mycobiome communities among the elderly Danes. In: Cell Symposia: Exercise Metabolism , 21-23 May 2017 , Gothenberg, Sweden. . (Published) |
| spellingShingle | QR Microbiology RA Public aspects of medicine Hajar Fauzan, Ahmad Faust, Karoline Castro Mejia, Josue Leonardo Kot, Witold Bechshøft, Rasmus Reitelseder, Søren Holm, Lars Nielsen, Dennis Sandris Deciphering the association networks of mycobiome communities among the elderly Danes |
| title | Deciphering the association networks of mycobiome communities among the elderly Danes |
| title_full | Deciphering the association networks of mycobiome communities among the elderly Danes |
| title_fullStr | Deciphering the association networks of mycobiome communities among the elderly Danes |
| title_full_unstemmed | Deciphering the association networks of mycobiome communities among the elderly Danes |
| title_short | Deciphering the association networks of mycobiome communities among the elderly Danes |
| title_sort | deciphering the association networks of mycobiome communities among the elderly danes |
| topic | QR Microbiology RA Public aspects of medicine |
| url | http://umpir.ump.edu.my/id/eprint/29968/ http://umpir.ump.edu.my/id/eprint/29968/1/CBIO2017%20Poster%20Programme_24%20April.pdf |