Optimization of lovastatin in solid-state fermentation using oil palm frond
Lovastatin plays a role in lowering the cholesterol level in the human blood, especially the bad cholesterol or low density lipoproteins (LDL). Concurrently, lovastatin increase the good cholesterol or high density lipoproteins (HDL), to prevent the formation of plaque inside the blood vessels. The...
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| Format: | Conference or Workshop Item |
| Language: | English |
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IOP Publishing
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/29912/ http://umpir.ump.edu.my/id/eprint/29912/7/Optimization%20of%20lovastatin%20in%20solid-state%20fermentation%20using%20oil%20palm%20frond.pdf |
| _version_ | 1848823393675116544 |
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| author | Nur Fathin Shamirah, Daud Farhan, Mohd Said J. M., Ho |
| author_facet | Nur Fathin Shamirah, Daud Farhan, Mohd Said J. M., Ho |
| author_sort | Nur Fathin Shamirah, Daud |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Lovastatin plays a role in lowering the cholesterol level in the human blood, especially the bad cholesterol or low density lipoproteins (LDL). Concurrently, lovastatin increase the good cholesterol or high density lipoproteins (HDL), to prevent the formation of plaque inside the blood vessels. The objective of this research was to experimentally optimize the lovastatin compound produced by Monascus purpureus FTC5357 under solid state fermentation (SSF) using oil palm frond (OPF). In order to identify the optimal condition to produce lovastatin, four parameters which were pH, initial moisture content, peptone and potassium, were optimized using Box–Behnken design. Based on the ANOVA analysis performed, initial moisture content, potassium and peptone contributed significantly to the lovastatin production. Meanwhile, pH had the least impact to the lovastatin production.. Peptone pronounced to be the most contributed factor, as the lovastatin production increased with the increasing of peptone in the substrate. Under optimized condition (pH 5.50, moisture content at 60%, 3.40 g of potassium, and 3.30 g of peptone) maximum lovastatin yield was 45.84 µg/g. The lovastatin produced through SSF using OPF as a substrate by Monascus purpureus FTC 5357 has a great potential to be utilized as a source of lovastatin in future. |
| first_indexed | 2025-11-15T02:56:26Z |
| format | Conference or Workshop Item |
| id | ump-29912 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:56:26Z |
| publishDate | 2020 |
| publisher | IOP Publishing |
| recordtype | eprints |
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| spelling | ump-299122021-02-16T07:51:02Z http://umpir.ump.edu.my/id/eprint/29912/ Optimization of lovastatin in solid-state fermentation using oil palm frond Nur Fathin Shamirah, Daud Farhan, Mohd Said J. M., Ho TP Chemical technology Lovastatin plays a role in lowering the cholesterol level in the human blood, especially the bad cholesterol or low density lipoproteins (LDL). Concurrently, lovastatin increase the good cholesterol or high density lipoproteins (HDL), to prevent the formation of plaque inside the blood vessels. The objective of this research was to experimentally optimize the lovastatin compound produced by Monascus purpureus FTC5357 under solid state fermentation (SSF) using oil palm frond (OPF). In order to identify the optimal condition to produce lovastatin, four parameters which were pH, initial moisture content, peptone and potassium, were optimized using Box–Behnken design. Based on the ANOVA analysis performed, initial moisture content, potassium and peptone contributed significantly to the lovastatin production. Meanwhile, pH had the least impact to the lovastatin production.. Peptone pronounced to be the most contributed factor, as the lovastatin production increased with the increasing of peptone in the substrate. Under optimized condition (pH 5.50, moisture content at 60%, 3.40 g of potassium, and 3.30 g of peptone) maximum lovastatin yield was 45.84 µg/g. The lovastatin produced through SSF using OPF as a substrate by Monascus purpureus FTC 5357 has a great potential to be utilized as a source of lovastatin in future. IOP Publishing 2020 Conference or Workshop Item PeerReviewed pdf en cc_by http://umpir.ump.edu.my/id/eprint/29912/7/Optimization%20of%20lovastatin%20in%20solid-state%20fermentation%20using%20oil%20palm%20frond.pdf Nur Fathin Shamirah, Daud and Farhan, Mohd Said and J. M., Ho (2020) Optimization of lovastatin in solid-state fermentation using oil palm frond. In: IOP Conference Series: Materials Science and Engineering, Energy Security and Chemical Engineering Congress , 17-19 July 2019 , Kuala Lumpur, Malaysia. pp. 1-11., 736 (022056). ISSN 1757-899X (Published) https://doi.org/10.1088/1757-899X/736/2/022056 |
| spellingShingle | TP Chemical technology Nur Fathin Shamirah, Daud Farhan, Mohd Said J. M., Ho Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title | Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title_full | Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title_fullStr | Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title_full_unstemmed | Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title_short | Optimization of lovastatin in solid-state fermentation using oil palm frond |
| title_sort | optimization of lovastatin in solid-state fermentation using oil palm frond |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/29912/ http://umpir.ump.edu.my/id/eprint/29912/ http://umpir.ump.edu.my/id/eprint/29912/7/Optimization%20of%20lovastatin%20in%20solid-state%20fermentation%20using%20oil%20palm%20frond.pdf |