Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering
In this study, bredigite nanoparticles were treated with an organosilane coupling agent to enhance its dispersability and compatibility with polymers. The polyhydroxybutyrate-co-hydroxyvaletare (PHBV) nanofibrous scaffolds containing treated bredigite (T-BR) nanoparticles were developed using electr...
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| Format: | Article |
| Language: | English |
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Elsevier
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/29678/ http://umpir.ump.edu.my/id/eprint/29678/1/Materials%20Today%20Proceedings%207%202019%20449%E2%80%93454.pdf |
| _version_ | 1848823336271872000 |
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| author | Monireh, Kouhi Mohammadhossein, Fathi Venugopal, Jayarama Reddy Seeram, Ramakrishna |
| author_facet | Monireh, Kouhi Mohammadhossein, Fathi Venugopal, Jayarama Reddy Seeram, Ramakrishna |
| author_sort | Monireh, Kouhi |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | In this study, bredigite nanoparticles were treated with an organosilane coupling agent to enhance its dispersability and compatibility with polymers. The polyhydroxybutyrate-co-hydroxyvaletare (PHBV) nanofibrous scaffolds containing treated bredigite (T-BR) nanoparticles were developed using electrospinning technique. It was found that pre-treating of bredigite was effective in enhancing nanoparticles dispersion both in the solution and in the PHBV matrix. Mechanical properties of the PHBV nanofibrous scaffolds were remarkably improved by incorporation of T-BR nanoparticles. The results also demonstrated that bioactivity and biodegradability rate of PHBV nanofibrous scaffolds were greatly altered by addition of BR and T-BR nanoparticles. Our study demonstrated that incorporation of T-BR nanoparticles within PHBV nanofibers may improve its mechanical performance and bioactivity, making it more appropriate materials for bone tissue engineering applications. |
| first_indexed | 2025-11-15T02:55:31Z |
| format | Article |
| id | ump-29678 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:55:31Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-296782020-10-22T02:53:43Z http://umpir.ump.edu.my/id/eprint/29678/ Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering Monireh, Kouhi Mohammadhossein, Fathi Venugopal, Jayarama Reddy Seeram, Ramakrishna R Medicine (General) In this study, bredigite nanoparticles were treated with an organosilane coupling agent to enhance its dispersability and compatibility with polymers. The polyhydroxybutyrate-co-hydroxyvaletare (PHBV) nanofibrous scaffolds containing treated bredigite (T-BR) nanoparticles were developed using electrospinning technique. It was found that pre-treating of bredigite was effective in enhancing nanoparticles dispersion both in the solution and in the PHBV matrix. Mechanical properties of the PHBV nanofibrous scaffolds were remarkably improved by incorporation of T-BR nanoparticles. The results also demonstrated that bioactivity and biodegradability rate of PHBV nanofibrous scaffolds were greatly altered by addition of BR and T-BR nanoparticles. Our study demonstrated that incorporation of T-BR nanoparticles within PHBV nanofibers may improve its mechanical performance and bioactivity, making it more appropriate materials for bone tissue engineering applications. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29678/1/Materials%20Today%20Proceedings%207%202019%20449%E2%80%93454.pdf Monireh, Kouhi and Mohammadhossein, Fathi and Venugopal, Jayarama Reddy and Seeram, Ramakrishna (2019) Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering. Materials Today: Proceedings, 7. pp. 449-454. (Published) http://www.sciencedirect.com https://doi.org/10.1016/j.matpr.2018.11.108 |
| spellingShingle | R Medicine (General) Monireh, Kouhi Mohammadhossein, Fathi Venugopal, Jayarama Reddy Seeram, Ramakrishna Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title | Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title_full | Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title_fullStr | Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title_full_unstemmed | Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title_short | Bredigite Reinforced Electrospun Nanofibers for Bone Tissue Engineering |
| title_sort | bredigite reinforced electrospun nanofibers for bone tissue engineering |
| topic | R Medicine (General) |
| url | http://umpir.ump.edu.my/id/eprint/29678/ http://umpir.ump.edu.my/id/eprint/29678/ http://umpir.ump.edu.my/id/eprint/29678/ http://umpir.ump.edu.my/id/eprint/29678/1/Materials%20Today%20Proceedings%207%202019%20449%E2%80%93454.pdf |