Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin
A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography–mass spectrometry (HPLC–HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect aga...
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Elsevier Ltd
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/29668/ http://umpir.ump.edu.my/id/eprint/29668/7/Inhibition%20of%20aglucosidase.pdf |
| _version_ | 1848823333718589440 |
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| author | Nazikussabah, Zaharudin Staerk, Dan Dragsted, Lars Ove |
| author_facet | Nazikussabah, Zaharudin Staerk, Dan Dragsted, Lars Ove |
| author_sort | Nazikussabah, Zaharudin |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography–mass spectrometry (HPLC–HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control. |
| first_indexed | 2025-11-15T02:55:28Z |
| format | Article |
| id | ump-29668 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:55:28Z |
| publishDate | 2019 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-296682020-11-19T01:46:12Z http://umpir.ump.edu.my/id/eprint/29668/ Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin Nazikussabah, Zaharudin Staerk, Dan Dragsted, Lars Ove QD Chemistry A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography–mass spectrometry (HPLC–HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control. Elsevier Ltd 2019-01-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29668/7/Inhibition%20of%20aglucosidase.pdf Nazikussabah, Zaharudin and Staerk, Dan and Dragsted, Lars Ove (2019) Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chemistry, 270. pp. 481-486. ISSN 0308-8146. (Published) https://doi.org/10.1016/j.foodchem.2018.07.142 https://doi.org/10.1016/j.foodchem.2018.07.142 |
| spellingShingle | QD Chemistry Nazikussabah, Zaharudin Staerk, Dan Dragsted, Lars Ove Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title | Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title_full | Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title_fullStr | Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title_full_unstemmed | Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title_short | Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| title_sort | inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin |
| topic | QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/29668/ http://umpir.ump.edu.my/id/eprint/29668/ http://umpir.ump.edu.my/id/eprint/29668/ http://umpir.ump.edu.my/id/eprint/29668/7/Inhibition%20of%20aglucosidase.pdf |