Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children
As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine it...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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AAAS
2020
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| Online Access: | http://umpir.ump.edu.my/id/eprint/29638/ http://umpir.ump.edu.my/id/eprint/29638/1/eaba2578.full%20Dr.AMahfuz.pdf |
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| author | Roslund, Marja I. Puhakka, Riikka Grönroos, Mira Nurminen, Noora Oikarinen, Sami Ahmad Mahfuz, Gazali Cinek, Ondřej Kramná, Lenka Siter, Nathan Vari, Heli K. Soininen, Laura Parajuli, Anirudra Rajaniemi, Juho Kinnunen, Tuure Laitinen, Olli H. Hyöty, Heikki Sinkkonen, Aki |
| author_facet | Roslund, Marja I. Puhakka, Riikka Grönroos, Mira Nurminen, Noora Oikarinen, Sami Ahmad Mahfuz, Gazali Cinek, Ondřej Kramná, Lenka Siter, Nathan Vari, Heli K. Soininen, Laura Parajuli, Anirudra Rajaniemi, Juho Kinnunen, Tuure Laitinen, Olli H. Hyöty, Heikki Sinkkonen, Aki |
| author_sort | Roslund, Marja I. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies. |
| first_indexed | 2025-11-15T02:55:22Z |
| format | Article |
| id | ump-29638 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:55:22Z |
| publishDate | 2020 |
| publisher | AAAS |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-296382020-10-20T03:28:47Z http://umpir.ump.edu.my/id/eprint/29638/ Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children Roslund, Marja I. Puhakka, Riikka Grönroos, Mira Nurminen, Noora Oikarinen, Sami Ahmad Mahfuz, Gazali Cinek, Ondřej Kramná, Lenka Siter, Nathan Vari, Heli K. Soininen, Laura Parajuli, Anirudra Rajaniemi, Juho Kinnunen, Tuure Laitinen, Olli H. Hyöty, Heikki Sinkkonen, Aki RA Public aspects of medicine RB Pathology RJ Pediatrics TP Chemical technology As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies. AAAS 2020-10-14 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/29638/1/eaba2578.full%20Dr.AMahfuz.pdf Roslund, Marja I. and Puhakka, Riikka and Grönroos, Mira and Nurminen, Noora and Oikarinen, Sami and Ahmad Mahfuz, Gazali and Cinek, Ondřej and Kramná, Lenka and Siter, Nathan and Vari, Heli K. and Soininen, Laura and Parajuli, Anirudra and Rajaniemi, Juho and Kinnunen, Tuure and Laitinen, Olli H. and Hyöty, Heikki and Sinkkonen, Aki (2020) Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sciences Advances, 6 (42). pp. 1-10. ISSN 2375-2548. (Published) https://advances.sciencemag.org/content/6/42/eaba2578 http:DOI: 10.1126/sciadv.aba2578 |
| spellingShingle | RA Public aspects of medicine RB Pathology RJ Pediatrics TP Chemical technology Roslund, Marja I. Puhakka, Riikka Grönroos, Mira Nurminen, Noora Oikarinen, Sami Ahmad Mahfuz, Gazali Cinek, Ondřej Kramná, Lenka Siter, Nathan Vari, Heli K. Soininen, Laura Parajuli, Anirudra Rajaniemi, Juho Kinnunen, Tuure Laitinen, Olli H. Hyöty, Heikki Sinkkonen, Aki Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title | Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title_full | Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title_fullStr | Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title_full_unstemmed | Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title_short | Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| title_sort | biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children |
| topic | RA Public aspects of medicine RB Pathology RJ Pediatrics TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/29638/ http://umpir.ump.edu.my/id/eprint/29638/ http://umpir.ump.edu.my/id/eprint/29638/ http://umpir.ump.edu.my/id/eprint/29638/1/eaba2578.full%20Dr.AMahfuz.pdf |