Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production
Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immuno...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
IEEE
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29304/ http://umpir.ump.edu.my/id/eprint/29304/13/Computational%20Investigation%20on%20Protein%20Sequence.pdf |
| Summary: | Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immunogenicity and protective capability against VTEC infections. Identification of potential B-cell epitopes for promising vaccine was carried out by evaluating the protein derived from non-O157 VTEC with the methods of beta turns, hydropathicity, surface accessibility and antigenicity. The methods were implemented in MATLAB. Our test results demonstrated that the VTEC-derived protein has plausible characteristics which provide significant insights for further investigations and will assist in finding potential drug targets/vaccine candidates. |
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