Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review
Hypertension is a significant public health challenge, responsible for a substantial proportion of deathsand disability globally. Calcium Channel Blockers (CCBs) are an important class for the treatment ofhypertension. However, most of CCBs must be taken more than once daily due to their low oralbio...
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| Format: | Conference or Workshop Item |
| Language: | English English |
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Trans Tech Publications Ltd
2021
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| Subjects: | |
| Online Access: | https://umpir.ump.edu.my/id/eprint/29132/ |
| _version_ | 1848827270471352320 |
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| author | Mahmood, Syed AL-japairai, Khater Ahmed Saeed |
| author_facet | Mahmood, Syed AL-japairai, Khater Ahmed Saeed |
| author_sort | Mahmood, Syed |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Hypertension is a significant public health challenge, responsible for a substantial proportion of deathsand disability globally. Calcium Channel Blockers (CCBs) are an important class for the treatment ofhypertension. However, most of CCBs must be taken more than once daily due to their low oralbioavailability and short half-lives leading to poor patient compliance. There is a growing need forenhancing drug delivery of CCBs to overcome the issues associated with their conventional dosageforms. The administration of the drug through the skin for systemic delivery has been recognized asone of the potential routes in hypertension treatment, especially when drugs suffer from lowbioavailability, short half-life, and undesirable side effects following oral administration. The mainlimitation of transdermal drug delivery is the resistance barrier of skin layers to penetrant molecules.Remarkable research efforts have been made worldwide to minimize the skin barrier and to createtransdermal systems of several CCBs via employing skin-enhancing potential. The persistent progressin this field is promising for development the transdermal dosage forms advance technology in the long term and being commercialized sooner rather than later. This review explores the investigations on the viability and applicability of systemic delivery of numerous CCBs through the skin |
| first_indexed | 2025-11-15T03:58:03Z |
| format | Conference or Workshop Item |
| id | ump-29132 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:58:03Z |
| publishDate | 2021 |
| publisher | Trans Tech Publications Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-291322025-08-20T00:35:26Z https://umpir.ump.edu.my/id/eprint/29132/ Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review Mahmood, Syed AL-japairai, Khater Ahmed Saeed TP Chemical technology Hypertension is a significant public health challenge, responsible for a substantial proportion of deathsand disability globally. Calcium Channel Blockers (CCBs) are an important class for the treatment ofhypertension. However, most of CCBs must be taken more than once daily due to their low oralbioavailability and short half-lives leading to poor patient compliance. There is a growing need forenhancing drug delivery of CCBs to overcome the issues associated with their conventional dosageforms. The administration of the drug through the skin for systemic delivery has been recognized asone of the potential routes in hypertension treatment, especially when drugs suffer from lowbioavailability, short half-life, and undesirable side effects following oral administration. The mainlimitation of transdermal drug delivery is the resistance barrier of skin layers to penetrant molecules.Remarkable research efforts have been made worldwide to minimize the skin barrier and to createtransdermal systems of several CCBs via employing skin-enhancing potential. The persistent progressin this field is promising for development the transdermal dosage forms advance technology in the long term and being commercialized sooner rather than later. This review explores the investigations on the viability and applicability of systemic delivery of numerous CCBs through the skin Trans Tech Publications Ltd 2021 Conference or Workshop Item PeerReviewed pdf en https://umpir.ump.edu.my/id/eprint/29132/1/8.%20Systemic%20delivery%20of%20calcium%20channel%20blockers%20for%20hypertension%20through%20transdermal%20delivery%20-%20a%20review.pdf pdf en https://umpir.ump.edu.my/id/eprint/29132/2/8.1%20Systemic%20delivery%20of%20calcium%20channel%20blockers%20for%20hypertension%20through%20transdermal%20delivery%20-%20a%20review.pdf Mahmood, Syed and AL-japairai, Khater Ahmed Saeed (2021) Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review. In: Materials Science Forum. Postgraduate Symposium on Industrial Science and Technology (SISTEC 2020). , 26 - 27 Aug 2020 , Google meet. pp. 204-208., 1025. ISBN 978-303573757-8 (Published) https://doi.org/10.4028/www.scientific.net/MSF.1025.204 |
| spellingShingle | TP Chemical technology Mahmood, Syed AL-japairai, Khater Ahmed Saeed Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title | Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title_full | Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title_fullStr | Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title_full_unstemmed | Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title_short | Systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| title_sort | systemic delivery of calcium channel blockers for hypertension through transdermal delivery - a review |
| topic | TP Chemical technology |
| url | https://umpir.ump.edu.my/id/eprint/29132/ https://umpir.ump.edu.my/id/eprint/29132/ |