Polymeric Nanoparticles for Brain Drug Delivery - A Review
Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many ther...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bentham Science
2020
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29112/ http://umpir.ump.edu.my/id/eprint/29112/1/Polymeric%20Nanoparticles%20for%20Brain%20Drug%20Delivery1.pdf |
| _version_ | 1848823212066996224 |
|---|---|
| author | Subashini, Raman Mahmood, Syed Ayah, R. Hilles Javed, M. Noushad Azmana, Motia AL-japairai, Khater Ahmed Saeed |
| author_facet | Subashini, Raman Mahmood, Syed Ayah, R. Hilles Javed, M. Noushad Azmana, Motia AL-japairai, Khater Ahmed Saeed |
| author_sort | Subashini, Raman |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery.
Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. |
| first_indexed | 2025-11-15T02:53:32Z |
| format | Article |
| id | ump-29112 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:53:32Z |
| publishDate | 2020 |
| publisher | Bentham Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-291122021-02-05T03:50:56Z http://umpir.ump.edu.my/id/eprint/29112/ Polymeric Nanoparticles for Brain Drug Delivery - A Review Subashini, Raman Mahmood, Syed Ayah, R. Hilles Javed, M. Noushad Azmana, Motia AL-japairai, Khater Ahmed Saeed TP Chemical technology Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Bentham Science 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/29112/1/Polymeric%20Nanoparticles%20for%20Brain%20Drug%20Delivery1.pdf Subashini, Raman and Mahmood, Syed and Ayah, R. Hilles and Javed, M. Noushad and Azmana, Motia and AL-japairai, Khater Ahmed Saeed (2020) Polymeric Nanoparticles for Brain Drug Delivery - A Review. Current Drug Metabolism, 21 (9). pp. 649-660. ISSN 1875-5453. (Published) https://doi.org/10.2174/1389200221666200508074348 https://doi.org/10.2174/1389200221666200508074348 |
| spellingShingle | TP Chemical technology Subashini, Raman Mahmood, Syed Ayah, R. Hilles Javed, M. Noushad Azmana, Motia AL-japairai, Khater Ahmed Saeed Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title | Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title_full | Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title_fullStr | Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title_full_unstemmed | Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title_short | Polymeric Nanoparticles for Brain Drug Delivery - A Review |
| title_sort | polymeric nanoparticles for brain drug delivery - a review |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/29112/ http://umpir.ump.edu.my/id/eprint/29112/ http://umpir.ump.edu.my/id/eprint/29112/ http://umpir.ump.edu.my/id/eprint/29112/1/Polymeric%20Nanoparticles%20for%20Brain%20Drug%20Delivery1.pdf |