Polymeric Nanoparticles for Brain Drug Delivery - A Review
Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many ther...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bentham Science
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/29112/ http://umpir.ump.edu.my/id/eprint/29112/1/Polymeric%20Nanoparticles%20for%20Brain%20Drug%20Delivery1.pdf |
| Summary: | Background: Blood-brain barrier (BBB) is playing a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery.
Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. |
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