Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical cros...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2020
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf |
| _version_ | 1848822967873568768 |
|---|---|
| author | Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose |
| author_facet | Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose |
| author_sort | Fatmawati, Adam |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical crosslinking is established at two points: hydroxyl (isovanillin)-sulfate (carrageenan) and aldehyde (isovanillin)-hydroxyl (carrageenan) with strong hydrogen bonds (H-bond) lengths of 1.74–1.79 Å. FTIR showed that isovanillin addition increased the intermolecular H-bond up to 57% as the OH-stretching is shifted from 3376 to 3356 cm−1. At 3 wt.% isovanillin concentration, the tensile strength of the biocomposite film increased to 49% and the hard capsule developed from the formulation solution disintegrated in 9 min. Upon contact with water, the H-bonds broke and caused the carrageenan fragments to dissolve in deionized water. The disintegration and mechanical properties of the crosslinked carrageenan biocomposite film made from renewable and low price materials facilitate the application of the film as hard capsules for drug delivery. |
| first_indexed | 2025-11-15T02:49:39Z |
| format | Article |
| id | ump-28109 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:49:39Z |
| publishDate | 2020 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-281092020-03-11T04:09:14Z http://umpir.ump.edu.my/id/eprint/28109/ Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose TP Chemical technology This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical crosslinking is established at two points: hydroxyl (isovanillin)-sulfate (carrageenan) and aldehyde (isovanillin)-hydroxyl (carrageenan) with strong hydrogen bonds (H-bond) lengths of 1.74–1.79 Å. FTIR showed that isovanillin addition increased the intermolecular H-bond up to 57% as the OH-stretching is shifted from 3376 to 3356 cm−1. At 3 wt.% isovanillin concentration, the tensile strength of the biocomposite film increased to 49% and the hard capsule developed from the formulation solution disintegrated in 9 min. Upon contact with water, the H-bonds broke and caused the carrageenan fragments to dissolve in deionized water. The disintegration and mechanical properties of the crosslinked carrageenan biocomposite film made from renewable and low price materials facilitate the application of the film as hard capsules for drug delivery. Taylor & Francis 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf Fatmawati, Adam and Mohd Aiman, Hamdan and Siti Hana, Abu Bakar and M. M., Yusoff and Rajan, Jose (2020) Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application. Chemical Engineering Communications. pp. 1-13. ISSN 1563-5201. (Published) https://www.tandfonline.com/doi/full/10.1080/00986445.2020.1731802 |
| spellingShingle | TP Chemical technology Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title | Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title_full | Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title_fullStr | Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title_full_unstemmed | Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title_short | Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| title_sort | molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf |