Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: Characterization, lyophilization and in-vivo evaluation

QR Code

Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: Characterization, lyophilization and in-vivo evaluation

Introduction: Insulin is given by injection, because when administered orally, it would be destroyed by enzymes in the digestive system, hence only about 0.1% reaches blood circulation. The purpose of the present study was to use pH sensitive polyelectrolyte methyl methacrylate (MMA)/itaconic acid (...

Full description

Bibliographic Details
Main Authors:	Mudassir, Jahanzeb, Yusrida, Darwis, Suriani, Muhamad, Khan, Arshad Ali
Format:	Article
Language:	English
Published:	Dovepress 2019
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/27329/ http://umpir.ump.edu.my/id/eprint/27329/1/Self-assembled%20insulin%20and%20nanogels%20polyelectrolyte%20complex.pdf

Similar Items

Synthesis And Characterization Of pH-Sensitive Polyelectrolyte Nanogels For Oral Delivery Of Bovine Serum Albumin And Insulin As Model Proteins
by: Mudassir, Jahanzeb
Published: (2018)

Freeze-dried lopinavir-loaded nanostructured lipid carriers for enhanced cellular uptake and bioavailability: statistical optimization, in vitro and in vivo evaluations.
by: Khan, Arshad Ali, et al.
Published: (2019)

Lyophilized hybrid nanostructured lipid carriers to enhance the cellular uptake of verapamil: statistical optimization and in vitro evaluation
by: Khan, Arshad Ali, et al.
Published: (2018)

A recent updates of polysaccharide based nanoparticulate oral preparation of insulin with special emphasis on in vivo application
by: Mandal, Uttam Kumar
Published: (2011)

Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin
by: Wong, Chun Yuen Jerry
Published: (2020)

PEC 2017 kembali
by: Zuraidi, Mansor
Published: (2016)

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment
by: Wong, C., et al.
Published: (2017)

Oral insulin delivery: existing barriers and current counter-strategies
by: Gedawy, A., et al.
Published: (2017)

Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
by: Kadir, Aminah
Published: (2015)

The Interaction of Insulin with the Insulin Receptor in a Membrane Environment
by: Sabapathy, Thiruvarutchelvan
Published: (2018)

Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities
by: Wong, C., et al.
Published: (2016)

Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus
by: Jin, X., et al.
Published: (2013)

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
by: Xie, Ling, et al.
Published: (2002)

Transdermal insulin on demand
by: Smith, Fiona
Published: (2024)

Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
by: Jamaludin, Ummu Kulthum, et al.
Published: (2017)

Design of pectinate nanoparticles as oral insulin carrier / Mohammad Tarmizi Mohd Mokhtar
by: Mohd Mokhtar, Mohammad Tarmizi
Published: (2014)

Developing an Oral-Insulin-Delivery System using GET-peptide-mediated transcytosis
by: Rehmani, Sahrish
Published: (2021)

Lyophilized amorphous dispersion of telmisartan in a combined carrier−alkalizer system: formulation development and in vivo study
by: AL-japairai, Khater Ahmed Saeed, et al.
Published: (2020)

Lyophilized amorphous dispersion of telmisartan in a combined carrier–alkalizer system: formulation development and in vivo study
by: Al-Japairai, Khater A. S., et al.
Published: (2020)

Association between polymorphisms of insulin and insulin receptor gene with childhood obesity in Malay population
by: Pey, Christinal Wen Teh, et al.
Published: (2016)

The insulin sensitivity of non-obese Malay subjects and the relationship between hyperlipidemia with insulin sensitivity
by: Hassan, Mohd Hashim Mohd, et al.
Published: (2005)

Modeling of Insulin Receptor Modeling of Insulin Receptor Binding & Recycling Binding & Recycling Subsystem
by: Ismail, Nor Faekah
Published: (2007)

Nanoparticles-in-beads made of alginate and chitosan derivatives as oral insulin carrier / Mulham Alfatama
by: Alfatama, Mulham
Published: (2018)

Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin
by: Wong, C., et al.
Published: (2018)

The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)

Metabolic Regulation of Insulin Secretion
by: Keane, Kevin, et al.
Published: (2014)

Understanding insulin endocrinology in decapod crustacea: Molecular modelling characterization of an insulin-binding protein and insulin-like peptides in the eastern spiny lobster, Sagmariasus verreauxi
by: Chandler, J., et al.
Published: (2017)

Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using ICING model
by: Jamaludin, Ummu Kulthum, et al.
Published: (2016)

Estimation of Plasma Insulin and Endogenous Insulin Secretion in Critically Ill Patients Using ICING Model
by: Ummu Kulthum, Jamaludin, et al.
Published: (2017)

Recent advancements in oral administration of insulin-loaded liposomal drug delivery systems for diabetes mellitus
by: Wong, Chun Yuen, et al.
Published: (2018)

Role of vitamin D and E in modulating glucose uptake and insulin sensitivity in insulin-resistant neuronal cells
by: Zaulkffali, Amirah Salwani
Published: (2017)

The influence of age and nutrients on insulin sensitivity
by: Chee, Carolyn
Published: (2016)

Cycloartane triterpenoid as an insulin mimicking agent
by: Darnis, Deny Susanti, et al.
Published: (2012)

(Dys)Regulation of Insulin Secretion by Macronutrients
by: Newsholme, Philip, et al.
Published: (2015)

Nutrient regulation of insulin secretion and action
by: Newsholme, Philip, et al.
Published: (2014)

Tactics in counseling patients to start insulin
by: Lee, Ping Yein, et al.
Published: (2013)

Enhanced Sensing Sensitivity of Long Period Fiber Grating by Self-Assembled Polyelectrolyte Multilayers
by: Ng, Foong Mun
Published: (2015)

Effectiveness of diabetes conversation Map™ on insulin acceptance among insulin refusal patients of type 2 diabetes mellitus
by: Tahir, Nur Shaharni Mohd
Published: (2018)

Oral insulin delivery system based on chitosan-completed carboxymethylated iota-carrageenan nanoparticles / Pratyusa Sahoo
by: Pratyusa, Sahoo
Published: (2019)

Design of pectin-chitosan nanoparticles as oral insulin carrier / Syed Mohamad Al-Azi Syed Othman
by: Syed Othman, Syed Mohamad Al-Azi
Published: (2015)