Effects of stent design on LDL accumulation at the carotid artery bifurcation
Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcati...
| Main Authors: | , , , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
Universiti Malaysia Pahang
2019
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/26483/ http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf |
| _version_ | 1848822547237306368 |
|---|---|
| author | Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad Xu, Xiao Y. |
| author_facet | Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad Xu, Xiao Y. |
| author_sort | Nasrul Hadi, Johari |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours
the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration. |
| first_indexed | 2025-11-15T02:42:58Z |
| format | Conference or Workshop Item |
| id | ump-26483 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T02:42:58Z |
| publishDate | 2019 |
| publisher | Universiti Malaysia Pahang |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-264832019-12-23T07:19:12Z http://umpir.ump.edu.my/id/eprint/26483/ Effects of stent design on LDL accumulation at the carotid artery bifurcation Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad Xu, Xiao Y. TJ Mechanical engineering and machinery Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration. Universiti Malaysia Pahang 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf pdf en http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf Nasrul Hadi, Johari and Menichini, Claudia and Hamady, Mohamad and Xu, Xiao Y. (2019) Effects of stent design on LDL accumulation at the carotid artery bifurcation. In: 6th International Conference on Computational and Mathematical Biomedical Engineering (CMBE 2019) , 10-12 June 2019 , Japan. pp. 1-4.. (Unpublished) (Unpublished) |
| spellingShingle | TJ Mechanical engineering and machinery Nasrul Hadi, Johari Menichini, Claudia Hamady, Mohamad Xu, Xiao Y. Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title | Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title_full | Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title_fullStr | Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title_full_unstemmed | Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title_short | Effects of stent design on LDL accumulation at the carotid artery bifurcation |
| title_sort | effects of stent design on ldl accumulation at the carotid artery bifurcation |
| topic | TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/26483/ http://umpir.ump.edu.my/id/eprint/26483/1/75.%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf http://umpir.ump.edu.my/id/eprint/26483/2/75.1%20Effects%20of%20stent%20design%20on%20ldl%20accumulation.pdf |