Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap
Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investi...
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| Format: | Conference or Workshop Item |
| Language: | English English |
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2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/26440/ http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf |
| _version_ | 1848822536618377216 |
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| author | Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. |
| author_facet | Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. |
| author_sort | Rashid, Shah Samiur |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investigated the antiproliferative effects of water and methanol extracts of the caps of three mushrooms (two variants of Hypsizygus tessellatus and Flammulina velutipes) against two breast cancer cell lines. In addition to the antiproliferation study, phytochemical identification and anti-oxidant investigation was also conducted. The phytochemical compositions of the extracts were identified using mass spectroscopy (UPLC-QTOF/MS). From the obtained results, the water extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps showed higher radical scavenging activities against DPPH free radicals and H2O2 compared to the methanol fractions. accordingly, the same extracts showed a good ferric reducing antioxidant power against ferric ions. Finally, the extracts showed considerable levels of antiproliferative activities against the breast cancer cells (MCF-7 and MDA-MB-231). Therefore, the findings suggest that the presence of different phytochemicals (polyphenols, alkaloids) become reactive synergistically to eliminate free radicals from the body and help to prevent the development of free radicals-related diseases like cancer. |
| first_indexed | 2025-11-15T02:42:48Z |
| format | Conference or Workshop Item |
| id | ump-26440 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T02:42:48Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-264402020-02-26T03:01:42Z http://umpir.ump.edu.my/id/eprint/26440/ Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. QC Physics Cancer is a burning issue in the world today as high mortality rates are associated with it. The World Health Organization (WHO) has advocated exploration of natural products as the alternative measure for cancer management as the synthetic drugs has very strong side effect. Thus, this study investigated the antiproliferative effects of water and methanol extracts of the caps of three mushrooms (two variants of Hypsizygus tessellatus and Flammulina velutipes) against two breast cancer cell lines. In addition to the antiproliferation study, phytochemical identification and anti-oxidant investigation was also conducted. The phytochemical compositions of the extracts were identified using mass spectroscopy (UPLC-QTOF/MS). From the obtained results, the water extracts of F. velutipes (Enoki) and white H. tessellatus (Bunapi shimeji) caps showed higher radical scavenging activities against DPPH free radicals and H2O2 compared to the methanol fractions. accordingly, the same extracts showed a good ferric reducing antioxidant power against ferric ions. Finally, the extracts showed considerable levels of antiproliferative activities against the breast cancer cells (MCF-7 and MDA-MB-231). Therefore, the findings suggest that the presence of different phytochemicals (polyphenols, alkaloids) become reactive synergistically to eliminate free radicals from the body and help to prevent the development of free radicals-related diseases like cancer. 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf pdf en http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf Rashid, Shah Samiur and Ukaegbu, Chinonso Ishmael and Hazrulrizawati, Hamid and Mohd Hasbi, Ab. Rahim and Zaidul, I. S. M. (2019) Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap. In: International Conference on Environment and Life Science (ICENLISC-19) , 21 May 2019 , Sydney, Australia. pp. 1-20.. (Unpublished) (Unpublished) |
| spellingShingle | QC Physics Rashid, Shah Samiur Ukaegbu, Chinonso Ishmael Hazrulrizawati, Hamid Mohd Hasbi, Ab. Rahim Zaidul, I. S. M. Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title | Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title_full | Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title_fullStr | Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title_full_unstemmed | Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title_short | Antioxidant and antiproliferative activities of the extracts of Hypsizygus tessellatus (brown and white var.) and Flammulina velutipes cap |
| title_sort | antioxidant and antiproliferative activities of the extracts of hypsizygus tessellatus (brown and white var.) and flammulina velutipes cap |
| topic | QC Physics |
| url | http://umpir.ump.edu.my/id/eprint/26440/ http://umpir.ump.edu.my/id/eprint/26440/1/38.%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf http://umpir.ump.edu.my/id/eprint/26440/2/38.1%20Antioxidant%20and%20antiproliferative%20activities%20of%20the%20extracts.pdf |