Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...
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| Format: | Article |
| Language: | English |
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Elsevier
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf |
| _version_ | 1848822437119000576 |
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| author | Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam |
| author_facet | Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam |
| author_sort | Poh, Yen Khor |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. |
| first_indexed | 2025-11-15T02:41:13Z |
| format | Article |
| id | ump-26063 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:41:13Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-260632019-11-27T02:32:42Z http://umpir.ump.edu.my/id/eprint/26063/ Insights on the synthesis of asymmetric curcumin derivatives and their biological activities Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. Elsevier 2019-12-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf Poh, Yen Khor and Mohd F. F., Mohd Aluwi and Kamal, Rullah and Kok, Wai Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234. (Published) https://doi.org/10.1016/j.ejmech.2019.111704 https://doi.org/10.1016/j.ejmech.2019.111704 |
| spellingShingle | QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_full | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_fullStr | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_full_unstemmed | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_short | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_sort | insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| topic | QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf |