Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal
Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the...
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Science Publishing Corporation
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf |
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| author | Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_facet | Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar |
| author_sort | Fatinah, Ab Rahman |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the formation of CBZ-SAC co-crystal. There were four different solvents (acetonitrile, ethanol, ethyl acetate and propanol) and two crystallization methods (slurry and stirring crystallization) used in this study. The crystals produced were characterized by Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared (FTIR) and optical microscopy. The findings revealed that only Form I of CBZ-SAC co-crystals was successfully formed for all parameters under studied. It was concluded that the type of solvents, crystallization methods and CBZ:SAC ratio used in this study did not play an important role on the CBZ-SAC Form I co-crystal formation for this system. |
| first_indexed | 2025-11-15T02:40:10Z |
| format | Article |
| id | ump-25796 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:40:10Z |
| publishDate | 2018 |
| publisher | Science Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-257962019-09-04T02:26:37Z http://umpir.ump.edu.my/id/eprint/25796/ Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar TP Chemical technology Active Pharmaceutical Ingredients (API) crystallized in its co-crystal form is believed to be able to improve the physicochemical properties of its pure crystal. Carbamazepine (CBZ) and saccharin (SAC) were used in this study in investigation of effect of solvents and crystallization methods on the formation of CBZ-SAC co-crystal. There were four different solvents (acetonitrile, ethanol, ethyl acetate and propanol) and two crystallization methods (slurry and stirring crystallization) used in this study. The crystals produced were characterized by Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared (FTIR) and optical microscopy. The findings revealed that only Form I of CBZ-SAC co-crystals was successfully formed for all parameters under studied. It was concluded that the type of solvents, crystallization methods and CBZ:SAC ratio used in this study did not play an important role on the CBZ-SAC Form I co-crystal formation for this system. Science Publishing Corporation 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf Fatinah, Ab Rahman and E. N., Engku Mat Nasir and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2018) Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal. International Journal of Engineering & Technology, 7 (4.18). pp. 90-94. ISSN 2227-524X. (Published) https://www.sciencepubco.com/index.php/ijet/article/view/21828 |
| spellingShingle | TP Chemical technology Fatinah, Ab Rahman E. N., Engku Mat Nasir Syarifah, Abd Rahim Raihana Z., Edros Nornizar, Anuar Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title | Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title_full | Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title_fullStr | Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title_full_unstemmed | Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title_short | Effect of Solvents and Crystallization Methods on the Formation of Carbamazepine-Saccharin Co-Crystal |
| title_sort | effect of solvents and crystallization methods on the formation of carbamazepine-saccharin co-crystal |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/ http://umpir.ump.edu.my/id/eprint/25796/1/Effect%20of%20Solvents%20and%20Crystallization%20Methods%20on%20the%20Formation%20of%20Carbamazepine.pdf |