Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

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Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA

The search of novel mPGES-1 inhibitors has recently intensified probably due to the superior safety in comparison to existing anti-inflammatory drugs. Although two mPGES-1 inhibitors have entered clinical trials, none has yet reached the market. In this study, we performed modifications guided by 3D...

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Bibliographic Details
Main Authors:	Mohd F. F., Mohd Aluwi, Rullah, Kamal, Koeberle, Andreas, Werz, Oliver, Nur Sakinah, Abdul Razak, Wei, Leong Sze, Fatimah, Salim, Nor Hadiani, Ismail, Ibrahim, Jantan, Wai, Lam K.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Subjects:	R Medicine (General) RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://umpir.ump.edu.my/id/eprint/25636/ http://umpir.ump.edu.my/id/eprint/25636/1/Design%20and%20synthesis%20of%20a%20novel%20mPGES-1%20lead%20inhibitor%20.pdf

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