Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering
Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Future Medicine Ltd.
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/1/Functionalized%20core_shell%20nanofibers%20for%20the.pdf |
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| author | Ezhilarasu, H. Sadiq, A. Ratheesh, G. Sridhar, S. Ramakrishna, Seeram Mohd Hasbi, Ab. Rahim M. M., Yusoff Rajan, Jose Venugopal, Jayarama Reddy |
| author_facet | Ezhilarasu, H. Sadiq, A. Ratheesh, G. Sridhar, S. Ramakrishna, Seeram Mohd Hasbi, Ab. Rahim M. M., Yusoff Rajan, Jose Venugopal, Jayarama Reddy |
| author_sort | Ezhilarasu, H. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts. Materials & methods: The fabricated core/shell nanofibers contained polycaprolactone/gelatin as the shell, and silk fibroin/VEGF as the core materials. Results: The results observed that the core/shell nanofibers interact to differentiate MSCs into smooth muscle cells by the expression of vascular smooth muscle cell (VSMC) contractile proteins α-actinin, myosin and F-actin. Conclusion: The functionalized polycaprolactone/gelatin/silk fibroin/VEGF (250 ng) core/shell nanofibers were fabricated for the controlled release of VEGF in a persistent manner for the differentiation of MSCs into smooth muscle cells for vascular tissue engineering. |
| first_indexed | 2025-11-15T02:37:03Z |
| format | Article |
| id | ump-24997 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:37:03Z |
| publishDate | 2019 |
| publisher | Future Medicine Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-249972019-10-14T06:46:36Z http://umpir.ump.edu.my/id/eprint/24997/ Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering Ezhilarasu, H. Sadiq, A. Ratheesh, G. Sridhar, S. Ramakrishna, Seeram Mohd Hasbi, Ab. Rahim M. M., Yusoff Rajan, Jose Venugopal, Jayarama Reddy QD Chemistry R Medicine (General) RM Therapeutics. Pharmacology Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts. Materials & methods: The fabricated core/shell nanofibers contained polycaprolactone/gelatin as the shell, and silk fibroin/VEGF as the core materials. Results: The results observed that the core/shell nanofibers interact to differentiate MSCs into smooth muscle cells by the expression of vascular smooth muscle cell (VSMC) contractile proteins α-actinin, myosin and F-actin. Conclusion: The functionalized polycaprolactone/gelatin/silk fibroin/VEGF (250 ng) core/shell nanofibers were fabricated for the controlled release of VEGF in a persistent manner for the differentiation of MSCs into smooth muscle cells for vascular tissue engineering. Future Medicine Ltd. 2019-01-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24997/1/Functionalized%20core_shell%20nanofibers%20for%20the.pdf Ezhilarasu, H. and Sadiq, A. and Ratheesh, G. and Sridhar, S. and Ramakrishna, Seeram and Mohd Hasbi, Ab. Rahim and M. M., Yusoff and Rajan, Jose and Venugopal, Jayarama Reddy (2019) Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering. Nanomedicine, 14 (2). pp. 201-214. ISSN 1743-5889. (Published) https://doi.org/10.2217/nnm-2018-0271 https://doi.org/10.2217/nnm-2018-0271 |
| spellingShingle | QD Chemistry R Medicine (General) RM Therapeutics. Pharmacology Ezhilarasu, H. Sadiq, A. Ratheesh, G. Sridhar, S. Ramakrishna, Seeram Mohd Hasbi, Ab. Rahim M. M., Yusoff Rajan, Jose Venugopal, Jayarama Reddy Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title | Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title_full | Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title_fullStr | Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title_full_unstemmed | Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title_short | Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| title_sort | functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering |
| topic | QD Chemistry R Medicine (General) RM Therapeutics. Pharmacology |
| url | http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/ http://umpir.ump.edu.my/id/eprint/24997/1/Functionalized%20core_shell%20nanofibers%20for%20the.pdf |