Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industrie...
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| Format: | Article |
| Language: | English |
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Wiley
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/24987/ http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf |
| _version_ | 1848822171589148672 |
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| author | Aljbour, Nawzat D. Beg, M. D. H. Jolius, Gimbun |
| author_facet | Aljbour, Nawzat D. Beg, M. D. H. Jolius, Gimbun |
| author_sort | Aljbour, Nawzat D. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industries. LMWC is often produced from HMWC by acid, enzymatic, or oxidative hydrolysis. Industrially, hydrolysis with dilute HCl is preferred, since it is simple, practical, and gives a high yield. In this study 2M HCl was used to prepare LMWC. A high average depolymerization yield of 87% was obtained. The LMWCs were characterized by FTIR spectroscopy, and the molecular weight and degree of deacetylation were determined. The prepared LMWCs are fully deacetylated, and their production by this method is reproducible. |
| first_indexed | 2025-11-15T02:37:00Z |
| format | Article |
| id | ump-24987 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:37:00Z |
| publishDate | 2019 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-249872019-05-21T03:20:47Z http://umpir.ump.edu.my/id/eprint/24987/ Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid Aljbour, Nawzat D. Beg, M. D. H. Jolius, Gimbun TP Chemical technology The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industries. LMWC is often produced from HMWC by acid, enzymatic, or oxidative hydrolysis. Industrially, hydrolysis with dilute HCl is preferred, since it is simple, practical, and gives a high yield. In this study 2M HCl was used to prepare LMWC. A high average depolymerization yield of 87% was obtained. The LMWCs were characterized by FTIR spectroscopy, and the molecular weight and degree of deacetylation were determined. The prepared LMWCs are fully deacetylated, and their production by this method is reproducible. Wiley 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf Aljbour, Nawzat D. and Beg, M. D. H. and Jolius, Gimbun (2019) Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid. Chemical Engineering and Technology. ISSN 1521-4125. (In Press / Online First) (In Press / Online First) https://doi.org/10.1002/ceat.201800527 https://doi.org/10.1002/ceat.201800527 |
| spellingShingle | TP Chemical technology Aljbour, Nawzat D. Beg, M. D. H. Jolius, Gimbun Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title | Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title_full | Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title_fullStr | Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title_full_unstemmed | Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title_short | Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid |
| title_sort | acid hydrolysis of chitosan to oligomers using hydrochloric acid |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/24987/ http://umpir.ump.edu.my/id/eprint/24987/ http://umpir.ump.edu.my/id/eprint/24987/ http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf |