Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle an...
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| Language: | English |
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Elsevier Ltd
2019
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| Online Access: | http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf |
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| author | Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. |
| author_facet | Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. |
| author_sort | Rubaiyi, M. Zaid |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle analysis were used to determine the sorbent characterization. A high degree of esterification (63.8%) and the contact angle (95.5°) confirmed hydrophobic nature and resulting bad wetting of the HMP extract, respectively. The methoxyl content in the pectin acted as an affinity-precursor of the pectin towards cholesterol due to its increased hydrophobicity. The maximum equilibrium uptake capacity of cholesterol of 370.5 mg/g (0.96 mmol/g) was observed by HMP. The experimental data showed good fitting for Freundlich isotherm equation and followed pseudo-first-order kinetic model with a correlation coefficient (R2) of 0.89–0.97 due to physisorption mechanism. Intra-particle model confirmed that the cholesterol sorption rate by HMP was significantly influenced by external mass transfer (surface diffusion) and intra-particle diffusion (diffusion control). It was also revealed that the HMP extracted from Hylocereus polyrhizus peels possess a high affinity towards cholesterol, making it an ideal hypolipidemic agent. |
| first_indexed | 2025-11-15T02:36:35Z |
| format | Article |
| id | ump-24883 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:36:35Z |
| publishDate | 2019 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-248832019-05-08T04:41:18Z http://umpir.ump.edu.my/id/eprint/24883/ Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. TP Chemical technology In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle analysis were used to determine the sorbent characterization. A high degree of esterification (63.8%) and the contact angle (95.5°) confirmed hydrophobic nature and resulting bad wetting of the HMP extract, respectively. The methoxyl content in the pectin acted as an affinity-precursor of the pectin towards cholesterol due to its increased hydrophobicity. The maximum equilibrium uptake capacity of cholesterol of 370.5 mg/g (0.96 mmol/g) was observed by HMP. The experimental data showed good fitting for Freundlich isotherm equation and followed pseudo-first-order kinetic model with a correlation coefficient (R2) of 0.89–0.97 due to physisorption mechanism. Intra-particle model confirmed that the cholesterol sorption rate by HMP was significantly influenced by external mass transfer (surface diffusion) and intra-particle diffusion (diffusion control). It was also revealed that the HMP extracted from Hylocereus polyrhizus peels possess a high affinity towards cholesterol, making it an ideal hypolipidemic agent. Elsevier Ltd 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf Rubaiyi, M. Zaid and Mishra, Puranjan and Zularisam, A. W. and Mimi Sakinah, A. M. (2019) Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent. International Journal of Biological Macromolecules. pp. 1-29. ISSN 0141-8130. (In Press / Online First) (In Press / Online First) https://doi.org/10.1016/j.ijbiomac.2019.03.143 https://doi.org/10.1016/j.ijbiomac.2019.03.143 |
| spellingShingle | TP Chemical technology Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title | Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title_full | Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title_fullStr | Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title_full_unstemmed | Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title_short | Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent |
| title_sort | hylocereus polyrhizus peel's high-methoxyl pectin: a potential source of hypolipidemic agent |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf |