Freeze-dried lopinavir-loaded nanostructured lipid carriers for enhanced cellular uptake and bioavailability: statistical optimization, in vitro and in vivo evaluations.

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Freeze-dried lopinavir-loaded nanostructured lipid carriers for enhanced cellular uptake and bioavailability: statistical optimization, in vitro and in vivo evaluations.

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations were freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8...

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Bibliographic Details
Main Authors:	Khan, Arshad Ali, Mudassir, Jahanzeb, Akhtar, Safia, Murugaiyah, Vikneswaran, Yusrida, Darwis
Format:	Article
Language:	English
Published:	MDPI 2019
Subjects:	QP Physiology
Online Access:	http://umpir.ump.edu.my/id/eprint/24708/ http://umpir.ump.edu.my/id/eprint/24708/1/Freeze-Dried%20Lopinavir-Loaded%20Nanostructured%20Lipid%20Carriers%20for%20Enhanced%20Cellular.pdf

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