In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to s...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf |
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| author | Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam |
| author_facet | Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam |
| author_sort | Azad, A. K. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g). |
| first_indexed | 2025-11-15T02:33:27Z |
| format | Article |
| id | ump-24086 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:33:27Z |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-240862019-02-11T02:35:16Z http://umpir.ump.edu.my/id/eprint/24086/ In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam TP Chemical technology The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g). Taylor & Francis 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf Azad, A. K. and Laboni, Farhina Rahman and Rashid, Harun and Ferdous, Sahena and Rashid, Shah Samiur and Nurkhalida, Kamal and Labu, Zubair Khalid and Islam, M. S. and Sarker, Zaidul Islam (2018) In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities. Natural Product Research: Formerly Natural Product Letters. pp. 1-4. ISSN 1478-6419 (print); 1478-6427 (online). (In Press / Online First) (In Press / Online First) https://doi.org/10.1080/14786419.2018.1538216 https://doi.org/10.1080/14786419.2018.1538216 |
| spellingShingle | TP Chemical technology Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title | In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title_full | In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title_fullStr | In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title_full_unstemmed | In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title_short | In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| title_sort | in vitro evaluation of cuscuta reflexa roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf |