Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study
In vitro biocompatibility of impact modified composites produced from poly(lactic acid) (PLA) and hydroxyapatite (HA) is reported in this study. Surface modification was previously used to facilitate the dispersion of HA in PLA, whereas impact property of the PLA‐HA composites was deliberately enhan...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/23874/ http://umpir.ump.edu.my/id/eprint/23874/2/Synergized%20poly%28lactic%20acid%29-hydroxyapatite%20composites.pdf |
| _version_ | 1848821908697513984 |
|---|---|
| author | Akindoyo, John Olabode Beg, M. D. H. Suriati, Ghazali Alam, A. K. M. Moshiul Heim, Hans Peter Feldmann, Maik |
| author_facet | Akindoyo, John Olabode Beg, M. D. H. Suriati, Ghazali Alam, A. K. M. Moshiul Heim, Hans Peter Feldmann, Maik |
| author_sort | Akindoyo, John Olabode |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | In vitro biocompatibility of impact modified composites produced from poly(lactic acid) (PLA) and hydroxyapatite (HA) is reported in this study. Surface modification was previously used to facilitate the dispersion of HA in PLA, whereas impact property of the PLA‐HA composites was deliberately enhanced as it was necessary. Herein, osteoblast cell culture assay was used to assess the possible effects of HA surface modification and impact modification on the cell behavior in physiological media. Furthermore, antimicrobial properties of the HA were assessed. Evidence of HA modification was confirmed through elemental and spectroscopic analysis. Incorporation of HA offered better cell attachment and proliferation to the PLA matrix, with significant increase in the cell viability (%). Also, modification of HA did not present obvious cytotoxicity to the PLA‐HA composite. Conversely, incorporation of impact modifier slowed down the rate of cell proliferation on the composite surface but facilitates increased wettability |
| first_indexed | 2025-11-15T02:32:49Z |
| format | Article |
| id | ump-23874 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:32:49Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-238742019-09-10T02:58:06Z http://umpir.ump.edu.my/id/eprint/23874/ Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study Akindoyo, John Olabode Beg, M. D. H. Suriati, Ghazali Alam, A. K. M. Moshiul Heim, Hans Peter Feldmann, Maik TP Chemical technology In vitro biocompatibility of impact modified composites produced from poly(lactic acid) (PLA) and hydroxyapatite (HA) is reported in this study. Surface modification was previously used to facilitate the dispersion of HA in PLA, whereas impact property of the PLA‐HA composites was deliberately enhanced as it was necessary. Herein, osteoblast cell culture assay was used to assess the possible effects of HA surface modification and impact modification on the cell behavior in physiological media. Furthermore, antimicrobial properties of the HA were assessed. Evidence of HA modification was confirmed through elemental and spectroscopic analysis. Incorporation of HA offered better cell attachment and proliferation to the PLA matrix, with significant increase in the cell viability (%). Also, modification of HA did not present obvious cytotoxicity to the PLA‐HA composite. Conversely, incorporation of impact modifier slowed down the rate of cell proliferation on the composite surface but facilitates increased wettability Wiley 2018-12-18 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23874/2/Synergized%20poly%28lactic%20acid%29-hydroxyapatite%20composites.pdf Akindoyo, John Olabode and Beg, M. D. H. and Suriati, Ghazali and Alam, A. K. M. Moshiul and Heim, Hans Peter and Feldmann, Maik (2018) Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study. Journal of Applied Polymer Science, 136 (15). ISSN 1097-4628. (In Press / Online First) (In Press / Online First) https://doi.org/10.1002/app.47400 https://doi.org/10.1002/app.47400 |
| spellingShingle | TP Chemical technology Akindoyo, John Olabode Beg, M. D. H. Suriati, Ghazali Alam, A. K. M. Moshiul Heim, Hans Peter Feldmann, Maik Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title | Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title_full | Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title_fullStr | Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title_full_unstemmed | Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title_short | Synergized poly(lactic acid)-hydroxyapatite composites: Biocompatibility study |
| title_sort | synergized poly(lactic acid)-hydroxyapatite composites: biocompatibility study |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/23874/ http://umpir.ump.edu.my/id/eprint/23874/ http://umpir.ump.edu.my/id/eprint/23874/ http://umpir.ump.edu.my/id/eprint/23874/2/Synergized%20poly%28lactic%20acid%29-hydroxyapatite%20composites.pdf |