Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in react...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Open
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/21781/ http://umpir.ump.edu.my/id/eprint/21781/1/Facile%20synthesis%20of%20N-.pdf |
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| author | Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Noorjahan Banu, Alitheen Muhammad Nazirul, Mubin Aziz |
| author_facet | Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Noorjahan Banu, Alitheen Muhammad Nazirul, Mubin Aziz |
| author_sort | Rizwan, Komal |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i). |
| first_indexed | 2025-11-15T02:25:15Z |
| format | Article |
| id | ump-21781 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:25:15Z |
| publishDate | 2018 |
| publisher | Springer Open |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-217812018-07-25T03:26:33Z http://umpir.ump.edu.my/id/eprint/21781/ Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Noorjahan Banu, Alitheen Muhammad Nazirul, Mubin Aziz QC Physics A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i). Springer Open 2018 Article PeerReviewed pdf en cc_by http://umpir.ump.edu.my/id/eprint/21781/1/Facile%20synthesis%20of%20N-.pdf Rizwan, Komal and Rasool, Nasir and Rehman, Ravya and Mahmood, Tariq and Ayub, Khurshid and Rasheed, Tahir and Ahmad, Gulraiz and Malik, Ayesha and Khan, Shakeel Ahmad and Akhtar, Muhammad Nadeem and Noorjahan Banu, Alitheen and Muhammad Nazirul, Mubin Aziz (2018) Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies. Chemistry Central Journal, 12 (18). pp. 1-9. ISSN 1752-153X. (Published) https://doi.org/10.1186/s13065-018-0451-0 doi: 10.1186/s13065-018-0451-0 |
| spellingShingle | QC Physics Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Noorjahan Banu, Alitheen Muhammad Nazirul, Mubin Aziz Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_full | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_fullStr | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_full_unstemmed | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_short | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_sort | facile synthesis of n- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via suzuki cross-coupling reaction: their characterization and dft studies |
| topic | QC Physics |
| url | http://umpir.ump.edu.my/id/eprint/21781/ http://umpir.ump.edu.my/id/eprint/21781/ http://umpir.ump.edu.my/id/eprint/21781/ http://umpir.ump.edu.my/id/eprint/21781/1/Facile%20synthesis%20of%20N-.pdf |