Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities
Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nont...
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf |
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| author | Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid |
| author_facet | Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid |
| author_sort | Ghawanmeh, Abdullah A. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell.
However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and
structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic
biofunctional compounds modified further affords a new entity in chemical structure with enhanced
activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of
synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is
discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug
and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine
nanoformulation, colchicine prodrugs and codrugs.
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| first_indexed | 2025-11-15T02:17:53Z |
| format | Article |
| id | ump-19831 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:17:53Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-198312018-10-25T01:08:26Z http://umpir.ump.edu.my/id/eprint/19831/ Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid QD Chemistry Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic biofunctional compounds modified further affords a new entity in chemical structure with enhanced activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine nanoformulation, colchicine prodrugs and codrugs. © Elsevier 2018-12-08 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf Ghawanmeh, Abdullah A. and K. F., Chong and Sarkar, Shaheen M. and Muntaz, Abu Bakar and Rizafizah, Othaman and Rozida, M. Khalid (2018) Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities. European Journal of Medicinal Chemistry, 144. pp. 229-242. ISSN 0223-5234. (Published) https://doi.org/10.1016/j.ejmech.2017.12.029 doi: 10.1016/j.ejmech.2017.12.029 |
| spellingShingle | QD Chemistry Ghawanmeh, Abdullah A. K. F., Chong Sarkar, Shaheen M. Muntaz, Abu Bakar Rizafizah, Othaman Rozida, M. Khalid Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title | Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title_full | Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title_fullStr | Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title_full_unstemmed | Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title_short | Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities |
| title_sort | colchicine prodrugs and codrugs: chemistry and bioactivities |
| topic | QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/ http://umpir.ump.edu.my/id/eprint/19831/8/fist-2017-kwok-Colchicine%20prodrugs%20and%20codrugs1.pdf |