Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response
The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2017
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/19820/ http://umpir.ump.edu.my/id/eprint/19820/1/fist-2017-mmyusoff.pdf |
| _version_ | 1848820967613136896 |
|---|---|
| author | Chahal, Sugandha Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar |
| author_facet | Chahal, Sugandha Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar |
| author_sort | Chahal, Sugandha |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. |
| first_indexed | 2025-11-15T02:17:52Z |
| format | Article |
| id | ump-19820 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:17:52Z |
| publishDate | 2017 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-198202018-04-24T08:11:31Z http://umpir.ump.edu.my/id/eprint/19820/ Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response Chahal, Sugandha Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar Q Science (General) QD Chemistry The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration. Taylor & Francis 2017-06-22 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19820/1/fist-2017-mmyusoff.pdf Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Mohammad Syaiful Bahari, Abdull Rasad and Anuj, Kumar (2017) Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response. International Journal of Polymeric Materials and Polymeric Biomaterials, 66 (3). pp. 115-122. ISSN 0091-4037(Print); 1563-535X(Online). (Published) https://doi.org/10.1080/00914037.2016.1190926 DOI: 10.1080/00914037.2016.1190926 |
| spellingShingle | Q Science (General) QD Chemistry Chahal, Sugandha Jahir Hussain, Fathima Shahitha M. M., Yusoff Mohammad Syaiful Bahari, Abdull Rasad Anuj, Kumar Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title | Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title_full | Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title_fullStr | Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title_full_unstemmed | Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title_short | Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response |
| title_sort | nanohydroxyapatite-coated hydroxyethyl cellulose/poly (vinyl) alcohol electrospun scaffolds and their cellular response |
| topic | Q Science (General) QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/19820/ http://umpir.ump.edu.my/id/eprint/19820/ http://umpir.ump.edu.my/id/eprint/19820/ http://umpir.ump.edu.my/id/eprint/19820/1/fist-2017-mmyusoff.pdf |