Novel Compounds Targeting InhA for TB Therapy
Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase,...
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf |
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| author | Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih |
| author_facet | Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih |
| author_sort | Almatar, Manaf |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase, might provide auspicious candidates which can be developed into novel antitubercular agents. In this review, we explain the role of InhA in the resistance of isoniazid. Furthermore, five classes of InhA inhibitors, which display novel binding modes and deliver evidence of their prosperous target engagement, have been debated. |
| first_indexed | 2025-11-15T02:17:21Z |
| format | Article |
| id | ump-19673 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:17:21Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-196732018-06-12T02:13:54Z http://umpir.ump.edu.my/id/eprint/19673/ Novel Compounds Targeting InhA for TB Therapy Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih Q Science (General) QR Microbiology Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase, might provide auspicious candidates which can be developed into novel antitubercular agents. In this review, we explain the role of InhA in the resistance of isoniazid. Furthermore, five classes of InhA inhibitors, which display novel binding modes and deliver evidence of their prosperous target engagement, have been debated. Elsevier 2018 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf Almatar, Manaf and Makky, Essam A. and Var, Isıl and Kayar, Begum and Koksal, Fatih (2018) Novel Compounds Targeting InhA for TB Therapy. Pharmacological Reports, 70 (2). pp. 217-226. ISSN 1734-1140. (Published) https://doi.org/10.1016/j.pharep.2017.09.001 doi: 10.1016/j.pharep.2017.09.001 |
| spellingShingle | Q Science (General) QR Microbiology Almatar, Manaf Makky, Essam A. Var, Isıl Kayar, Begum Koksal, Fatih Novel Compounds Targeting InhA for TB Therapy |
| title | Novel Compounds Targeting InhA for TB Therapy |
| title_full | Novel Compounds Targeting InhA for TB Therapy |
| title_fullStr | Novel Compounds Targeting InhA for TB Therapy |
| title_full_unstemmed | Novel Compounds Targeting InhA for TB Therapy |
| title_short | Novel Compounds Targeting InhA for TB Therapy |
| title_sort | novel compounds targeting inha for tb therapy |
| topic | Q Science (General) QR Microbiology |
| url | http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/ http://umpir.ump.edu.my/id/eprint/19673/1/Novel%20compounds%20targeting%20InhA%20for%20TB%20therapy-fist-2018.pdf |