Antimicrobial peptides as an alternative to anti-tuberculosis drugs
Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon...
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| Format: | Article |
| Language: | English |
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Elsevier
2018
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| Online Access: | http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf |
| _version_ | 1848820934987743232 |
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| author | Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih |
| author_facet | Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih |
| author_sort | Almatar, Manaf |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon modes of action to effectively overcome M. tuberculosis. Within this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that comprise a section of the innate immune system, are currently the leading potential agents for the treatment of TB. Many studies have recently illustrated the capability of anti-mycobacterial peptides to disrupt the normal mycobacterial cell wall function through various modes, thereby interacting with the intracellular targets, as well as encompassing nucleic acids, enzymes and organelles. This review presents a wide array of antimicrobial activities, alongside the associated properties of the AMPs that could be utilized as potential agents in therapeutic tactics for TB treatment. |
| first_indexed | 2025-11-15T02:17:21Z |
| format | Article |
| id | ump-19672 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:17:21Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-196722018-06-04T07:42:50Z http://umpir.ump.edu.my/id/eprint/19672/ Antimicrobial peptides as an alternative to anti-tuberculosis drugs Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih Q Science (General) Tuberculosis (TB) presently accounts for high global mortality and morbidity rates, despite the introduction four decades ago of the affordable and efficient four-drugs (isoniazid, rifampicin, pyrazinamide and ethambutol). Thus, a strong need exists for new drugs with special structures and uncommon modes of action to effectively overcome M. tuberculosis. Within this scope, antimicrobial peptides (AMPs), which are small, cationic and amphipathic peptides that comprise a section of the innate immune system, are currently the leading potential agents for the treatment of TB. Many studies have recently illustrated the capability of anti-mycobacterial peptides to disrupt the normal mycobacterial cell wall function through various modes, thereby interacting with the intracellular targets, as well as encompassing nucleic acids, enzymes and organelles. This review presents a wide array of antimicrobial activities, alongside the associated properties of the AMPs that could be utilized as potential agents in therapeutic tactics for TB treatment. Elsevier 2018 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf Almatar, Manaf and Makky, Essam A. and Yakici, Gulfer and Var, Isil and Kayar, Begum and Koksal, Fatih (2018) Antimicrobial peptides as an alternative to anti-tuberculosis drugs. Pharmacological Research, 128. pp. 288-305. ISSN 1043-6618. (Published) https://doi.org/10.1016/j.phrs.2017.10.011 doi: 10.1016/j.phrs.2017.10.011 |
| spellingShingle | Q Science (General) Almatar, Manaf Makky, Essam A. Yakici, Gulfer Var, Isil Kayar, Begum Koksal, Fatih Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title | Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title_full | Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title_fullStr | Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title_full_unstemmed | Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title_short | Antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| title_sort | antimicrobial peptides as an alternative to anti-tuberculosis drugs |
| topic | Q Science (General) |
| url | http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/ http://umpir.ump.edu.my/id/eprint/19672/1/Antimicrobial%20peptides%20as%20an%20alternative%20to%20anti-tuberculosis%20drugs-fist-2018.pdf |