Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution
This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the ra...
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| Format: | Article |
| Language: | English English |
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Springer
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/18680/ http://umpir.ump.edu.my/id/eprint/18680/1/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution.pdf http://umpir.ump.edu.my/id/eprint/18680/6/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution%201.pdf |
| _version_ | 1848820734289248256 |
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| author | Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar |
| author_facet | Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar |
| author_sort | Khairool Azizul, Mohammad |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method. |
| first_indexed | 2025-11-15T02:14:09Z |
| format | Article |
| id | ump-18680 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T02:14:09Z |
| publishDate | 2017 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-186802018-05-24T03:09:47Z http://umpir.ump.edu.my/id/eprint/18680/ Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar TP Chemical technology This study aimed to investigate the metastable zone width (MSZW) and the nucleation order of carbamazepine–saccharin (CBZ–SAC) co-crystals via slow cooling crystallisation, to obtain the kinetic value using Kashchiev–Borissova–Hammond–Roberts (KBHR) technique and to deduce the induction time, the radius of the critical nucleus and the interfacial energy of the CBZ–SAC co-crystals via fast cooling. Slow cooling experiments with cooling/heating rates of 0.8, 0.6, 0.4 and 0.2 °C min−1 were applied to determine the crystallisation and the dissolution temperature of CBZ–SAC co-crystals at SAC:CBZ ratios of (3.5, 3.0, 2.5, 2.0 and 1.0) and CBZ concentrations of 19.14, 17.96, 17.06 and 15.83 mg mL−1. Then, fast cooling experiments were run at CBZ concentration of 17.96 mg mL−1 and SAC:CBZ mole ratio of 2.0. Nucleation kinetics, such as MSZW, nucleation order, nucleation kinetic constant and interfacial energy, was determined and analysed. KBHR method was applied to analyse the kinetics value and compared with isothermal method. The nucleation orders obtained from slow cooling method were in between 1.65 and 4.9, which were within the range for nucleation of organic compounds. The results of KBHR method in determining the kinetic values of CBZ–SAC co-crystals were similar to those of the isothermal method. Springer 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/18680/1/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/18680/6/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution%201.pdf Khairool Azizul, Mohammad and Syarifah, Abd Rahim and Mohd Rushdi, Abu Bakar (2017) Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution. Journal of Thermal Analysis and Calorimetry. pp. 1-7. ISSN 1388-6150 (print); 1588-2926 (online). (Published) https://link.springer.com/article/10.1007/s10973-017-6483-1 DOI: 10.1007/s10973-017-6483-1 |
| spellingShingle | TP Chemical technology Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title | Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title_full | Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title_fullStr | Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title_full_unstemmed | Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title_short | Kinetics and Nucleation Mechanism of Carbamazepine–Saccharin Co-Crystals in Ethanol Solution |
| title_sort | kinetics and nucleation mechanism of carbamazepine–saccharin co-crystals in ethanol solution |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/18680/ http://umpir.ump.edu.my/id/eprint/18680/ http://umpir.ump.edu.my/id/eprint/18680/ http://umpir.ump.edu.my/id/eprint/18680/1/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution.pdf http://umpir.ump.edu.my/id/eprint/18680/6/Kinetics%20and%20Nucleation%20Mechanism%20of%20Carbamazepine%E2%80%93Saccharin%20Co-Crystals%20in%20Ethanol%20Solution%201.pdf |