Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles
In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Malaysia Pahang
2016
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf |
| _version_ | 1848820127156404224 |
|---|---|
| author | Senthilnathan, B. Maheswaran, A. Gopalasatheeskumar, K. Masilamani, K. Raihana Z., Edros |
| author_facet | Senthilnathan, B. Maheswaran, A. Gopalasatheeskumar, K. Masilamani, K. Raihana Z., Edros |
| author_sort | Senthilnathan, B. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal
concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were
prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-EPNP5).
The prepared nanoparticles were characterized for its particle size, zeta potential, drug content, entrapment
efficiency and invitro drug release profile. The preformulation study results confirmed the compatibility
between the drug and other excipients used in the formulation. The optimized formulation was selected based
on its particle size, entrapment efficiency and in vitro drug release profile. The formulation which contains
300mg of Eudragit S100 (EPNP5) was selected as optimized concentration for the controlled release of
Pregabalin for a period of 24hrs. |
| first_indexed | 2025-11-15T02:04:30Z |
| format | Article |
| id | ump-16156 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T02:04:30Z |
| publishDate | 2016 |
| publisher | Penerbit Universiti Malaysia Pahang |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-161562018-02-01T06:04:57Z http://umpir.ump.edu.my/id/eprint/16156/ Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles Senthilnathan, B. Maheswaran, A. Gopalasatheeskumar, K. Masilamani, K. Raihana Z., Edros TP Chemical technology In this work, polymeric nanoparticles containing Pregabalin was prepared and optimized the ideal concentration of polymer based on its in vitro release profile for a period of 24hrs.The nanoparticles were prepared by solvent displacement method using various concentrations of Eudragit S100 (EPNP1-EPNP5). The prepared nanoparticles were characterized for its particle size, zeta potential, drug content, entrapment efficiency and invitro drug release profile. The preformulation study results confirmed the compatibility between the drug and other excipients used in the formulation. The optimized formulation was selected based on its particle size, entrapment efficiency and in vitro drug release profile. The formulation which contains 300mg of Eudragit S100 (EPNP5) was selected as optimized concentration for the controlled release of Pregabalin for a period of 24hrs. Penerbit Universiti Malaysia Pahang 2016 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf Senthilnathan, B. and Maheswaran, A. and Gopalasatheeskumar, K. and Masilamani, K. and Raihana Z., Edros (2016) Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles. International Journal of Engineering Technology And Sciences (IJETS), 6 (1). pp. 64-70. ISSN 2289-697X. (Published) http://ijets.ump.edu.my/images/archive/Vol6/9.pdf DOI: 10.15282/ijets.6.2016.1.9.1059 |
| spellingShingle | TP Chemical technology Senthilnathan, B. Maheswaran, A. Gopalasatheeskumar, K. Masilamani, K. Raihana Z., Edros Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title | Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title_full | Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title_fullStr | Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title_full_unstemmed | Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title_short | Formulation and Evaluation of Pregabalin Loaded Eudragit S100 Nanoparticles |
| title_sort | formulation and evaluation of pregabalin loaded eudragit s100 nanoparticles |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/ http://umpir.ump.edu.my/id/eprint/16156/1/ftek-2016-9.pdf |