Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method
Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (...
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IACSIT Press
2017
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| Online Access: | http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf |
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| author | Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle |
| author_facet | Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle |
| author_sort | Fatinah, Ab Rahman |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the
melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal. |
| first_indexed | 2025-11-15T01:52:58Z |
| format | Article |
| id | ump-13162 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:52:58Z |
| publishDate | 2017 |
| publisher | IACSIT Press |
| recordtype | eprints |
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| spelling | ump-131622019-10-30T07:38:11Z http://umpir.ump.edu.my/id/eprint/13162/ Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle TP Chemical technology Co-crystal plays a critical role in the pharmaceutical industry and becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and co-crystal former (CCF) of fumaric acid (FUM) and succinic acid (SA) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method for CBZ-FUM system and in all methods for CBZ-SA system. The findings from this analysis revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvents systems. DSC analysis had shown that the melting point of CBZ-FUM and CBZ-SA co-crystals were in the range similar to the previous study. The characterization using FT-IR indicated that the functional groups which include amides and carboxylic acids were presented in the co-crystal produced. Further study on the co-crystal solubility and dissolution rate is needed in order to access the efficacy of the co-crystal since the screening methods have been successfully confirmed the formation of the co-crystal. IACSIT Press 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf Fatinah, Ab Rahman and Syarifah, Abd Rahim and Tan, Chou C. and Han, L. S. and Noor Ashila, Ramle (2017) Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method. International Journal of Chemical Engineering and Applications (IJCEA), 8 (2). pp. 136-140. ISSN 2010-0221. (Published) http://www.ijcea.org/index.php?m=content&c=index&a=show&catid=86&id=1023 DOI: 10.18178/ijcea.2017.8.2.645 |
| spellingShingle | TP Chemical technology Fatinah, Ab Rahman Syarifah, Abd Rahim Tan, Chou C. Han, L. S. Noor Ashila, Ramle Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title | Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title_full | Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title_fullStr | Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title_full_unstemmed | Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title_short | Carbamazepine-Fumaric Acid and Carbamazepine-Succinic Acid Co-crystal Screening Using Solution Based Method |
| title_sort | carbamazepine-fumaric acid and carbamazepine-succinic acid co-crystal screening using solution based method |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/ http://umpir.ump.edu.my/id/eprint/13162/1/Carbamazepine-Fumaric%20Acid%20and%20Carbamazepine-Succinic%20Acid%20Co-crystal%20Screening%20Using%20Solution%20Based%20Method.pdf |