Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis
Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier Ltd
2015
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| Online Access: | http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf |
| _version_ | 1848818945396572160 |
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| author | Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin |
| author_facet | Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin |
| author_sort | Fatanah, M. Suhaimi |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score. |
| first_indexed | 2025-11-15T01:45:43Z |
| format | Article |
| id | ump-11198 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T01:45:43Z |
| publishDate | 2015 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-111982019-07-17T02:52:42Z http://umpir.ump.edu.my/id/eprint/11198/ Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin TJ Mechanical engineering and machinery Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score. Elsevier Ltd 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf Fatanah, M. Suhaimi and Chase, J. Geoffrey and Pretty, G. Christopher and Shaw, M. Geoffrey and Normy Norfiza, A. Razak and Ummu Kulthum, Jamaludin (2015) Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis. IFAC-PapersOnLine, 48 (20). pp. 372-376. ISSN 2405-8963. (Published) http://dx.doi.org/10.1016/j.ifacol.2015.10.168 DOI: 10.1016/j.ifacol.2015.10.168 |
| spellingShingle | TJ Mechanical engineering and machinery Fatanah, M. Suhaimi Chase, J. Geoffrey Pretty, G. Christopher Shaw, M. Geoffrey Normy Norfiza, A. Razak Ummu Kulthum, Jamaludin Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title | Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title_full | Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title_fullStr | Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title_full_unstemmed | Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title_short | Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis |
| title_sort | insulin sensitivity as a model-based marker for sepsis diagnosis |
| topic | TJ Mechanical engineering and machinery |
| url | http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/ http://umpir.ump.edu.my/id/eprint/11198/1/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf http://umpir.ump.edu.my/id/eprint/11198/7/Insulin%20Sensitivity%20as%20a%20Model-Based%20Marker%20for%20Sepsis%20Diagnosis.pdf |