Network analysis of drug side effects and indications / Yousoff Effendy Mohd Ali
This thesis aims to understand drug relationship based on drug side effect and indication through network analysis. Two drug networks are constructed using the SIDER 4.1 dataset which are (a) drug-side effect network and (b) drug-indication network. These networks have been analyzed using network...
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| Format: | Thesis |
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2018
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| Online Access: | http://studentsrepo.um.edu.my/9478/ http://studentsrepo.um.edu.my/9478/1/Yousoff_Effendy_Mohd_Ali.pdf http://studentsrepo.um.edu.my/9478/9/yousoff.pdf |
| Summary: | This thesis aims to understand drug relationship based on drug side effect and indication
through network analysis. Two drug networks are constructed using the SIDER 4.1
dataset which are (a) drug-side effect network and (b) drug-indication network. These
networks have been analyzed using network analysis to describe the element-level and
network-level properties. Various measurements in network analysis are used to describe
those properties including centralities, HITS, PageRank and Burt’s constraint. Based on
the node measurements in network analysis, all drugs in the networks were ranked and a
few prominent drugs have been identified in both networks. The prominent drugs were
used to explain the application of network analysis on finding or predicting potentially new
uses of drugs called drug repositioning. Interestingly, some of the prominent drugs were
appeared in list of successful drug repositioning and some of the predicted new uses were
already appeared in current clinical studies. |
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