Alkaloids from Alstonia Macrophylla / Lim Siew Huah

The Malaysian plant, Alstonia macrophylla Wall, was investigated for its alkaloidal content and the results are summarized in the Table below. A total of 90 alkaloids were isolated and characterized from the leaf and stem-bark of A. macrophylla. Of these, 30 are new alkaloids. The leaf extract of A....

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Main Author:	Lim, Siew Huah
Format:	Thesis
Published:	2013
Subjects:	Q Science (General)
Online Access:	http://studentsrepo.um.edu.my/4964/ http://studentsrepo.um.edu.my/4964/1/PhD_Thesis%2DLim_Siew_Huah.pdf

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author	Lim, Siew Huah
author_facet	Lim, Siew Huah
author_sort	Lim, Siew Huah
building	UM Research Repository
collection	Online Access
description	The Malaysian plant, Alstonia macrophylla Wall, was investigated for its alkaloidal content and the results are summarized in the Table below. A total of 90 alkaloids were isolated and characterized from the leaf and stem-bark of A. macrophylla. Of these, 30 are new alkaloids. The leaf extract of A. macrophylla yielded a total of 13 new alkaloids, including a macroline indole 1, a macroline oxindole 16, eight akuammiline alkaloids (compounds 24, 25, 26, 27, 28, 29, 30, and 31), a sarpagine alkaloid 32, and two ajmaline alkaloids (compounds 33 and 34). The stem-bark extract of A. macrophylla gave a total of 19 new alkaloids. These include, in addition to the akuammiline and sarpagine alkaloids found in the leaf extract (24 and 32, respectively), compound 2, 3, 4, 17, the linearly fused bisindole alkaloids, lumutinines A‒E (7175), the macroline-macroline bisindoles, lumusidines AD (7780) and perhentidines A‒B (81and 82), and the macrolinepleiocarpamine bisindole alkaloids, villalstonidines B (86) and F (87). Perhentidines A‒B (81 and 82), perhentinine (83), villalstonine (88) and macrocarpamine (90), showed pronounced cytotoxicity toward KB cells (IC50 2.644.06 g/mL), while lumutinines A‒E (71‒75), macralstonidine (76), lumusidines A-C (77‒79), anhydromacralstonine (85), and villalstonidine B (86) showed moderate cytotoxicity toward KB cells (IC50 4.3018.14 g/mL). Compounds 24, 25, 26, 29, 31, 32, lumusidine D (80), and macralstonine (84) showed strong activity in circumventing MDR in vincristine-resistant KB cells (IC50 0.055.03 g/mL).
first_indexed	2025-11-14T13:31:43Z
format	Thesis
id	um-4964
institution	University Malaya
institution_category	Local University
last_indexed	2025-11-14T13:31:43Z
publishDate	2013
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spelling	um-49642015-04-01T02:16:12Z Alkaloids from Alstonia Macrophylla / Lim Siew Huah Lim, Siew Huah Q Science (General) The Malaysian plant, Alstonia macrophylla Wall, was investigated for its alkaloidal content and the results are summarized in the Table below. A total of 90 alkaloids were isolated and characterized from the leaf and stem-bark of A. macrophylla. Of these, 30 are new alkaloids. The leaf extract of A. macrophylla yielded a total of 13 new alkaloids, including a macroline indole 1, a macroline oxindole 16, eight akuammiline alkaloids (compounds 24, 25, 26, 27, 28, 29, 30, and 31), a sarpagine alkaloid 32, and two ajmaline alkaloids (compounds 33 and 34). The stem-bark extract of A. macrophylla gave a total of 19 new alkaloids. These include, in addition to the akuammiline and sarpagine alkaloids found in the leaf extract (24 and 32, respectively), compound 2, 3, 4, 17, the linearly fused bisindole alkaloids, lumutinines A‒E (7175), the macroline-macroline bisindoles, lumusidines AD (7780) and perhentidines A‒B (81and 82), and the macrolinepleiocarpamine bisindole alkaloids, villalstonidines B (86) and F (87). Perhentidines A‒B (81 and 82), perhentinine (83), villalstonine (88) and macrocarpamine (90), showed pronounced cytotoxicity toward KB cells (IC50 2.644.06 g/mL), while lumutinines A‒E (71‒75), macralstonidine (76), lumusidines A-C (77‒79), anhydromacralstonine (85), and villalstonidine B (86) showed moderate cytotoxicity toward KB cells (IC50 4.3018.14 g/mL). Compounds 24, 25, 26, 29, 31, 32, lumusidine D (80), and macralstonine (84) showed strong activity in circumventing MDR in vincristine-resistant KB cells (IC50 0.055.03 g/mL). 2013 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/4964/1/PhD_Thesis%2DLim_Siew_Huah.pdf Lim, Siew Huah (2013) Alkaloids from Alstonia Macrophylla / Lim Siew Huah. PhD thesis, University of Malaya. http://studentsrepo.um.edu.my/4964/
spellingShingle	Q Science (General) Lim, Siew Huah Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title	Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title_full	Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title_fullStr	Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title_full_unstemmed	Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title_short	Alkaloids from Alstonia Macrophylla / Lim Siew Huah
title_sort	alkaloids from alstonia macrophylla / lim siew huah
topic	Q Science (General)
url	http://studentsrepo.um.edu.my/4964/ http://studentsrepo.um.edu.my/4964/1/PhD_Thesis%2DLim_Siew_Huah.pdf

Alkaloids from Alstonia Macrophylla / Lim Siew Huah

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