Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi
This study was conducted to evaluate the effects of topical application of an ethanol extract of Goniothalamus umbrosus on the rate of skin wound healing closure and the histology of healed wound. The animal groups were topically treated with 0.2 ml of each vehicle (gum acacia), Intrasite gel, 100 a...
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| Format: | Thesis |
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2012
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| Online Access: | http://pendeta.um.edu.my/client/default/search/detailnonmodal/ent:$002f$002fSD_ILS$002f987$002fSD_ILS:987894/one?qu=Acute+toxicity%2C+antioxidant+and+wound+healing http://studentsrepo.um.edu.my/4231/1/WASAN_M.J_HUSSAIN_AL%2DKADMI__[SGF_070031].pdf |
| _version_ | 1848772594646384640 |
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| author | Al-Kadmi, Wasan Mj Hussain |
| author_facet | Al-Kadmi, Wasan Mj Hussain |
| author_sort | Al-Kadmi, Wasan Mj Hussain |
| building | UM Research Repository |
| collection | Online Access |
| description | This study was conducted to evaluate the effects of topical application of an ethanol extract of Goniothalamus umbrosus on the rate of skin wound healing closure and the histology of healed wound. The animal groups were topically treated with 0.2 ml of each vehicle (gum acacia), Intrasite gel, 100 and 200 mg/ml of ethanol leaf extract, respectively. An area of uniform wound 2.00 cm in diameter was excised from the nape of the dorsal neck of all rats with the aid of round seal using circular stamp.Macroscopically, skin wound dressed with rhizomes extract and Intrasite gel showed significantly healed earlier than those treated with vehicle.Histological analysis of healed skin wounds dressed with G. umbrosus ethanol leaf extract showed comparatively at wound closure and healed wound contained less inflammatory cells and more collagen with angiogenesis compared to wounds dressed with vehicle.
In conclusion, skin wounds dressed with leaf extract showed significantly enhanced the acceleration of wound healing enclosure in rats. |
| first_indexed | 2025-11-14T13:29:00Z |
| format | Thesis |
| id | um-4231 |
| institution | University Malaya |
| institution_category | Local University |
| last_indexed | 2025-11-14T13:29:00Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | um-42312014-10-08T14:03:11Z Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi Al-Kadmi, Wasan Mj Hussain TP Chemical technology This study was conducted to evaluate the effects of topical application of an ethanol extract of Goniothalamus umbrosus on the rate of skin wound healing closure and the histology of healed wound. The animal groups were topically treated with 0.2 ml of each vehicle (gum acacia), Intrasite gel, 100 and 200 mg/ml of ethanol leaf extract, respectively. An area of uniform wound 2.00 cm in diameter was excised from the nape of the dorsal neck of all rats with the aid of round seal using circular stamp.Macroscopically, skin wound dressed with rhizomes extract and Intrasite gel showed significantly healed earlier than those treated with vehicle.Histological analysis of healed skin wounds dressed with G. umbrosus ethanol leaf extract showed comparatively at wound closure and healed wound contained less inflammatory cells and more collagen with angiogenesis compared to wounds dressed with vehicle. In conclusion, skin wounds dressed with leaf extract showed significantly enhanced the acceleration of wound healing enclosure in rats. 2012 Thesis NonPeerReviewed application/pdf http://studentsrepo.um.edu.my/4231/1/WASAN_M.J_HUSSAIN_AL%2DKADMI__[SGF_070031].pdf http://pendeta.um.edu.my/client/default/search/detailnonmodal/ent:$002f$002fSD_ILS$002f987$002fSD_ILS:987894/one?qu=Acute+toxicity%2C+antioxidant+and+wound+healing Al-Kadmi, Wasan Mj Hussain (2012) Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi. Masters thesis, University of Malaya. http://studentsrepo.um.edu.my/4231/ |
| spellingShingle | TP Chemical technology Al-Kadmi, Wasan Mj Hussain Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title | Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title_full | Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title_fullStr | Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title_full_unstemmed | Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title_short | Acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / Wasan MJ Hussain Al-Kadmi |
| title_sort | acute toxicity, antioxidant and wound healing potential of ethanolic extract of goniothalamus umbrosus in rats / wasan mj hussain al-kadmi |
| topic | TP Chemical technology |
| url | http://pendeta.um.edu.my/client/default/search/detailnonmodal/ent:$002f$002fSD_ILS$002f987$002fSD_ILS:987894/one?qu=Acute+toxicity%2C+antioxidant+and+wound+healing http://pendeta.um.edu.my/client/default/search/detailnonmodal/ent:$002f$002fSD_ILS$002f987$002fSD_ILS:987894/one?qu=Acute+toxicity%2C+antioxidant+and+wound+healing http://studentsrepo.um.edu.my/4231/1/WASAN_M.J_HUSSAIN_AL%2DKADMI__[SGF_070031].pdf |