Periodontal and microbial responses of obese individuals after short term non-surgical periodontal therapy / Khairunnisa Md Tahir
The association between obesity and chronic periodontitis has been well documented. However, the response of obesity on periodontal and microbial following non–surgical periodontal therapy (NSPT) remains unclear. Thus, this study is aimed to investigate the response of obesity on the clinical par...
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| Format: | Thesis |
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2017
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| Online Access: | http://studentsrepo.um.edu.my/10430/ http://studentsrepo.um.edu.my/10430/4/nisa.pdf |
| Summary: | The association between obesity and chronic periodontitis has been well documented.
However, the response of obesity on periodontal and microbial following non–surgical
periodontal therapy (NSPT) remains unclear. Thus, this study is aimed to investigate the
response of obesity on the clinical parameters and periodontal pathogens profile
following short term of NSPT. The study also assessed the correlation between clinical
parameters and periodontal pathogens profile. This prospective study involved 30 obese
(test group) and 30 non–obese (control group). Obese is defined as individual who have
BMI ≥ 30.0 kg/m2
. Ethical approval was obtained (DF PE1501/0085(L)). The clinical
parameters (visible plaque index (VPI), gingival bleeding index (GBI), probing pocket
depth (PPD) and clinical attachment loss (CAL)) were obtained from the Malaysian
Periodontal Database and Biobank Database (MPDBS). The subgingival plaques
samples were collected at baseline and at 12 weeks following NSPT by previous
researchers. Quantitative real–time polymerase chain reaction (qPCR) was used to
quantify the mean count of periodontal pathogens. The obese group showed greater
reduction in mean differences of VPI and GBI (69% and 53%) at 12 weeks post NSPT
compared to the non–obese group (15% and 15%) respectively. After adjusting the
confounding factors, the obese group was found as a potential associated (p < 0.0001)
factor in mean changes of VPI and GBI. Following NSPT, means PPD and CAL in both
groups was significantly reduced after 12 weeks except for CAL in the non–obese
groups. In terms of periodontal pathogens profile, the obese group showed significant
reduction only on P. intermedia (up to 49%) compared with reduction means count of
P. gingivalis, T. forsythia and A. actinomycetemcomitans (up to 100%) in the non–obese
group. No correlation was found between the clinical parameters and periodontal
pathogens profiles in the obese groups with chronic periodontitis following 12 weeks
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NSPT. From the findings, it can be summarized that the obese group showed higher VPI
and GBI but lower PPD and CAL compared to the non–obese group following 12 weeks
NSPT. Furthermore, lower P. gingivalis and T. forsythia but higher P. intermedia were
observed in the obese group at 12 weeks post NSPT. No correlation was found between
clinical parameters and periodontal pathogens profile in the obese group. |
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