Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy
A 37-year-old Malay woman presented with progressive deterioration in vision and was diagnosed with advanced proliferative diabetic retinopathy with neovascular glaucoma. Intravitreal ranibizumab injection (an anti-vascular endothelial growth factor) was administered prior to vitrectomy. Slit lamp a...
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| Format: | Article |
| Language: | English |
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Department of Surgery, UKM Medical Centre
2011
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| Online Access: | http://journalarticle.ukm.my/931/ http://journalarticle.ukm.my/931/1/Dramatic_Response_of_Iris_and_Retinal.pdf |
| _version_ | 1848809362537054208 |
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| author | Malisa A, Mae-Lynn CB, |
| author_facet | Malisa A, Mae-Lynn CB, |
| author_sort | Malisa A, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | A 37-year-old Malay woman presented with progressive deterioration in vision and was diagnosed with advanced proliferative diabetic retinopathy with neovascular glaucoma. Intravitreal ranibizumab injection (an anti-vascular endothelial growth factor) was administered prior to vitrectomy. Slit lamp assessment 2 days post-injection revealed significant regression of both iris and retinal neovascularisation. This resulted in adequate reduction of intra-ocular pressure prior to surgery. In addition, the regression of retinal vessels reduced the risk of intra-operative haemorrhage, thus aiding the surgical excision of the fibrovascular membranes. Periodic post-operative assessment in the first 3 weeks showed minimal inflammation and no recurrence of vitreous haemorrhage. This case illustrates that intravitreal ranibizumab has a role as an adjunct therapy prior to diabetic vitrectomy to significantly reduce the risk of intra-ocular haemorrhage. |
| first_indexed | 2025-11-14T23:13:24Z |
| format | Article |
| id | ukm-931 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:13:24Z |
| publishDate | 2011 |
| publisher | Department of Surgery, UKM Medical Centre |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ukm-9312016-12-14T06:28:21Z http://journalarticle.ukm.my/931/ Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy Malisa A, Mae-Lynn CB, A 37-year-old Malay woman presented with progressive deterioration in vision and was diagnosed with advanced proliferative diabetic retinopathy with neovascular glaucoma. Intravitreal ranibizumab injection (an anti-vascular endothelial growth factor) was administered prior to vitrectomy. Slit lamp assessment 2 days post-injection revealed significant regression of both iris and retinal neovascularisation. This resulted in adequate reduction of intra-ocular pressure prior to surgery. In addition, the regression of retinal vessels reduced the risk of intra-operative haemorrhage, thus aiding the surgical excision of the fibrovascular membranes. Periodic post-operative assessment in the first 3 weeks showed minimal inflammation and no recurrence of vitreous haemorrhage. This case illustrates that intravitreal ranibizumab has a role as an adjunct therapy prior to diabetic vitrectomy to significantly reduce the risk of intra-ocular haemorrhage. Department of Surgery, UKM Medical Centre 2011-04-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/931/1/Dramatic_Response_of_Iris_and_Retinal.pdf Malisa A, and Mae-Lynn CB, (2011) Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy. Journal of Surgical Academia, 1 (1). pp. 67-70. ISSN 2231-7481 http://jsurgacad.com/ |
| spellingShingle | Malisa A, Mae-Lynn CB, Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title | Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title_full | Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title_fullStr | Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title_full_unstemmed | Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title_short | Dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| title_sort | dramatic response of iris and retinal neovascularisation following usage of intravitreal ranibizumab as pre-operative adjunct in vitrectomy for advanced proliferative diabetic retinopathy |
| url | http://journalarticle.ukm.my/931/ http://journalarticle.ukm.my/931/ http://journalarticle.ukm.my/931/1/Dramatic_Response_of_Iris_and_Retinal.pdf |