Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women
Cancers of the ovary and corpus uteri afflict 5% and 3.6% Malaysian women respectively. Ovarian cancer (OC) remained the deadliest gynaecological malignancy in perimenopausal women mainly due to the lack of symptoms until the disease had spread. Ultrasonography could provide a preliminary screening...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2007
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| Online Access: | http://journalarticle.ukm.my/1936/ http://journalarticle.ukm.my/1936/1/07._66-79_%28MH_035%29.pdf |
| _version_ | 1848809704136900608 |
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| author | Adeeb N, Nur-Azurah AG, Ong FB, Shamsuddin K, Seri SS, Noor-Aini MY, |
| author_facet | Adeeb N, Nur-Azurah AG, Ong FB, Shamsuddin K, Seri SS, Noor-Aini MY, |
| author_sort | Adeeb N, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Cancers of the ovary and corpus uteri afflict 5% and 3.6% Malaysian women respectively. Ovarian cancer (OC) remained the deadliest gynaecological malignancy in perimenopausal women mainly due to the lack of symptoms until the disease had spread. Ultrasonography could provide a preliminary screening allowing the clinician to tailor subsequent management and counselling for these women. To support the basis for selective screening, a study on 517 urban disease free women aged 45 years and above, uterus-intact, non-users of HRT was undertaken. This study presented normograms of ovary, uterus and endometrium derived from entry ultrasound assessment. The sample comprised of 58.0% premenopaused and 42.0% postmenopaused women with an average age of 51.27±5.35 years old. Over two thirds were Chinese followed by Malays and Indians. The findings indicated that the average uterine size and endometrial thickness (ET) was 7.21±1.67x4.36±1.30cm and 6.36±3.73mm respectively. Premenopausal women had larger uterus compared to those postmenopaused (p<0.0005) and atrophy of the uterus with age and menopause was demonstrable regardless of ethnicity. Likewise, mean ET in the premenopaused was thicker than the postmenopaused (p<0.0005), showing a gradual decrease with age. Early postmenopausal women demonstrated ET of <5mm, eventually reaching 2mm in women >70 years old. From these findings, a cut-off of <5.0mm was considered clinically acceptable in normal postmenopaused regardless of ethnicity. Nearly one fifth (18.9%) had uterine fibroids, a quarter (25%) in premenopausal women as compared to 10% postmenopaused (p<0.0005). The mean right and left ovarian volume (OV) was 5.48±7.85cm3 and 5.80±16.78cm3 respectively. There was a gradual decline in OV with age and menopause from about 7cm3 at age 45-49 years to less than 1.5cm3 at 70 years giving a clinical norm OV of <7.5cm3 and <3.5cm3 respectively in pre and postmenopausal Malaysian women. Benign ovarian cysts seen in 2.9% had a mean size of 65.14±88.22cm3. In conclusion, ET and OV normograms should be made available for the Malaysian population to facilitate screening for gynaecological malignancies |
| first_indexed | 2025-11-14T23:18:50Z |
| format | Article |
| id | ukm-1936 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:18:50Z |
| publishDate | 2007 |
| publisher | Penerbit UKM |
| recordtype | eprints |
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| spelling | ukm-19362016-12-14T06:30:29Z http://journalarticle.ukm.my/1936/ Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women Adeeb N, Nur-Azurah AG, Ong FB, Shamsuddin K, Seri SS, Noor-Aini MY, Cancers of the ovary and corpus uteri afflict 5% and 3.6% Malaysian women respectively. Ovarian cancer (OC) remained the deadliest gynaecological malignancy in perimenopausal women mainly due to the lack of symptoms until the disease had spread. Ultrasonography could provide a preliminary screening allowing the clinician to tailor subsequent management and counselling for these women. To support the basis for selective screening, a study on 517 urban disease free women aged 45 years and above, uterus-intact, non-users of HRT was undertaken. This study presented normograms of ovary, uterus and endometrium derived from entry ultrasound assessment. The sample comprised of 58.0% premenopaused and 42.0% postmenopaused women with an average age of 51.27±5.35 years old. Over two thirds were Chinese followed by Malays and Indians. The findings indicated that the average uterine size and endometrial thickness (ET) was 7.21±1.67x4.36±1.30cm and 6.36±3.73mm respectively. Premenopausal women had larger uterus compared to those postmenopaused (p<0.0005) and atrophy of the uterus with age and menopause was demonstrable regardless of ethnicity. Likewise, mean ET in the premenopaused was thicker than the postmenopaused (p<0.0005), showing a gradual decrease with age. Early postmenopausal women demonstrated ET of <5mm, eventually reaching 2mm in women >70 years old. From these findings, a cut-off of <5.0mm was considered clinically acceptable in normal postmenopaused regardless of ethnicity. Nearly one fifth (18.9%) had uterine fibroids, a quarter (25%) in premenopausal women as compared to 10% postmenopaused (p<0.0005). The mean right and left ovarian volume (OV) was 5.48±7.85cm3 and 5.80±16.78cm3 respectively. There was a gradual decline in OV with age and menopause from about 7cm3 at age 45-49 years to less than 1.5cm3 at 70 years giving a clinical norm OV of <7.5cm3 and <3.5cm3 respectively in pre and postmenopausal Malaysian women. Benign ovarian cysts seen in 2.9% had a mean size of 65.14±88.22cm3. In conclusion, ET and OV normograms should be made available for the Malaysian population to facilitate screening for gynaecological malignancies Penerbit UKM 2007 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1936/1/07._66-79_%28MH_035%29.pdf Adeeb N, and Nur-Azurah AG, and Ong FB, and Shamsuddin K, and Seri SS, and Noor-Aini MY, (2007) Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women. Medicine & Health, 2 (1). pp. 66-79. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php |
| spellingShingle | Adeeb N, Nur-Azurah AG, Ong FB, Shamsuddin K, Seri SS, Noor-Aini MY, Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title | Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title_full | Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title_fullStr | Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title_full_unstemmed | Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title_short | Normograms of ovarian volume, Uterine size and endometrial thickness in urban midlife Malaysia women |
| title_sort | normograms of ovarian volume, uterine size and endometrial thickness in urban midlife malaysia women |
| url | http://journalarticle.ukm.my/1936/ http://journalarticle.ukm.my/1936/ http://journalarticle.ukm.my/1936/1/07._66-79_%28MH_035%29.pdf |