Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek
Tacrolimus is an immunosuppressant commonly used for long term in transplant patients to prevent organ rejection. Its use faces clinical challenges in achieving optimum dose for all patients. There are wide variation in doses of tacrolimus required for patients resulting in different drug levels and...
| Main Authors: | , |
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| Format: | Research Reports |
| Language: | English |
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Research Management Institute (RMI)
2010
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| Online Access: | https://ir.uitm.edu.my/id/eprint/9751/ |
| _version_ | 1848802947513712640 |
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| author | Salleh, Mohd Zaki Teh, Lay Kek |
| author_facet | Salleh, Mohd Zaki Teh, Lay Kek |
| author_sort | Salleh, Mohd Zaki |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Tacrolimus is an immunosuppressant commonly used for long term in transplant patients to prevent organ rejection. Its use faces clinical challenges in achieving optimum dose for all patients. There are wide variation in doses of tacrolimus required for patients resulting in different drug levels and unpredictable drug responses. Certain patients are predisposed to an increased susceptibility to acute rejection while many are at risk of adverse effects of tacrolimus. Tacrolimus is a substrate for both P-glycoprotein (Pgp, encoded by the gene MDR1) and CYP3A's. Differences in the intestinal P-glycoprotein and hepatic and intestinal cytochrome P4503A activities have been postulated as contributing to the wide inter-patients variations in drug levels and responses. We therefore aim to investigate the impact of the genetic polymorphism as well as expression level of MDR1 in transplant patients receiving tacrolimus. |
| first_indexed | 2025-11-14T21:31:27Z |
| format | Research Reports |
| id | uitm-9751 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:31:27Z |
| publishDate | 2010 |
| publisher | Research Management Institute (RMI) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-97512022-05-25T03:42:23Z https://ir.uitm.edu.my/id/eprint/9751/ Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek Salleh, Mohd Zaki Teh, Lay Kek Genetic polymorphisms Transplantation of organs, tissues, etc. Tacrolimus is an immunosuppressant commonly used for long term in transplant patients to prevent organ rejection. Its use faces clinical challenges in achieving optimum dose for all patients. There are wide variation in doses of tacrolimus required for patients resulting in different drug levels and unpredictable drug responses. Certain patients are predisposed to an increased susceptibility to acute rejection while many are at risk of adverse effects of tacrolimus. Tacrolimus is a substrate for both P-glycoprotein (Pgp, encoded by the gene MDR1) and CYP3A's. Differences in the intestinal P-glycoprotein and hepatic and intestinal cytochrome P4503A activities have been postulated as contributing to the wide inter-patients variations in drug levels and responses. We therefore aim to investigate the impact of the genetic polymorphism as well as expression level of MDR1 in transplant patients receiving tacrolimus. Research Management Institute (RMI) 2010 Research Reports NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/9751/1/LP_MOHD%20ZAKI%20SALLEH%20RMI%2010_24.pdf Salleh, Mohd Zaki and Teh, Lay Kek (2010) Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek. (2010) [Research Reports] (Submitted) |
| spellingShingle | Genetic polymorphisms Transplantation of organs, tissues, etc. Salleh, Mohd Zaki Teh, Lay Kek Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title | Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title_full | Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title_fullStr | Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title_full_unstemmed | Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title_short | Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek |
| title_sort | tacrolimus pharmacogenetics: the influence of genetic polymorphisms of cyp3a5, mdrl and pregnane x receptor (pxr) in transplant patients / professor dr. mohd zaki salleh and associate prof. dr teh lay kek |
| topic | Genetic polymorphisms Transplantation of organs, tissues, etc. |
| url | https://ir.uitm.edu.my/id/eprint/9751/ |