Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman
Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in th...
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Online Access: | https://ir.uitm.edu.my/id/eprint/759/ |
| _version_ | 1848802395253899264 |
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| author | Osman, Muhamad Faridz |
| author_facet | Osman, Muhamad Faridz |
| author_sort | Osman, Muhamad Faridz |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Chalcones represent a group of compounds with interesting biological activities that are
formed from an aldol condensation between a benzaldehyde and an acetophenone in the
presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium
hydroxide in organic solvents, in this study three different chalcones were synthesized
using a solventless procedure. The solvent-free synthesis of three chalcones was carried
out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4-
methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and
pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter
reaction time (within five minutes). The results seemed to indicate the success of the
solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For
comparison, the three chalcones were also synthesized by the traditional aldol
condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield
(62-72%) and required longer reaction time (62-75 min). |
| first_indexed | 2025-11-14T21:22:40Z |
| format | Thesis |
| id | uitm-759 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T21:22:40Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-7592016-05-26T07:58:10Z https://ir.uitm.edu.my/id/eprint/759/ Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman Osman, Muhamad Faridz QD Chemistry Chalcones represent a group of compounds with interesting biological activities that are formed from an aldol condensation between a benzaldehyde and an acetophenone in the presence of NaOH as a catalyst. Although traditionally synthesized using aqueous sodium hydroxide in organic solvents, in this study three different chalcones were synthesized using a solventless procedure. The solvent-free synthesis of three chalcones was carried out by grinding the benzaldehyde (3-nitro, 4-methoxy, 4-chloro) and 4- methoxyacetophenone in the presence of solid sodium hydroxide with a mortar and pestle. Chalcones were obtained in high yields (76-86%), high purity, and shorter reaction time (within five minutes). The results seemed to indicate the success of the solvent-free aldol synthesis which is simple, highly efficient and eco-friendly. For comparison, the three chalcones were also synthesized by the traditional aldol condensation catalyzed by aqueous sodium hydroxide in ethanol afforded lower yield (62-72%) and required longer reaction time (62-75 min). 2009 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/759/1/TD_MUHAMAD%20FARIDZ%20OSMAN_09_5%201.pdf Osman, Muhamad Faridz (2009) Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman. (2009) Degree thesis, thesis, Universiti Teknologi MARA. <http://terminalib.uitm.edu.my/759.pdf> |
| spellingShingle | QD Chemistry Osman, Muhamad Faridz Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title | Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title_full | Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title_fullStr | Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title_full_unstemmed | Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title_short | Solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (NaOH) / Muhamad Faridz Osman |
| title_sort | solvent-free synthesis of chalcone by aldol condensation catalyzed by solid sodium hydroxyde (naoh) / muhamad faridz osman |
| topic | QD Chemistry |
| url | https://ir.uitm.edu.my/id/eprint/759/ |