Formulation and evaluation of cream from stem barks of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry
The demand of herbal cream has increased rapidly in the market due to the herbs’ natural content which does not pose any side effects on the human skin. In the present study, we investigated the ethyl acetate extract of Pithecellobium jiringa (P. jiringa) stem barks as antibacterial cream. The an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Teknologi MARA Cawangan Pahang
2020
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| Online Access: | https://ir.uitm.edu.my/id/eprint/31114/ |
| _version_ | 1848807672322719744 |
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| author | Mat Hussin, Zurhana Irfan Zakry, Nurin Adila Zakry |
| author_facet | Mat Hussin, Zurhana Irfan Zakry, Nurin Adila Zakry |
| author_sort | Mat Hussin, Zurhana |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | The demand of herbal cream has increased rapidly in the market due to the herbs’ natural
content which does not pose any side effects on the human skin. In the present study, we
investigated the ethyl acetate extract of Pithecellobium jiringa (P. jiringa) stem barks as
antibacterial cream. The antioxidant potential of the P. jiringa extract was evaluated by using
2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Six formulations of
antibacterial creams (oil in water) were prepared and labelled as F1 to F6. All formulations
were characterized by different parameters such as pH, spread ability and stability. These
formulations were then investigated for their antibacterial activity against several bacteria such
as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K.
pneumonia) and Bacillus cereus (B. cereus) by using agar disc diffusion technique. The DPPH
scavenging activity showed moderate radical scavenging activity with IC50 value was 46.25
µg/mL. Among the six formulations, F6 showed the good spread ability, homogeneity,
appearance and pH. The formulation did not show any phase separation and was easy to
remove. The F6 formulation also showed no irritations on skin such as redness, edema, or
erythema in irritancy studies. In microbiological assay, F6 formulation exhibited the largest
zone inhibition against Staphylococcus aureus which was 11.52 mm at the concentration of
2.0% w/v. Therefore, the study suggests that the F6 can be safely used for the consumers that
have skin irritations caused by bacteria. |
| first_indexed | 2025-11-14T22:46:33Z |
| format | Article |
| id | uitm-31114 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T22:46:33Z |
| publishDate | 2020 |
| publisher | Universiti Teknologi MARA Cawangan Pahang |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-311142020-12-27T01:39:02Z https://ir.uitm.edu.my/id/eprint/31114/ Formulation and evaluation of cream from stem barks of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry gadingst Mat Hussin, Zurhana Irfan Zakry, Nurin Adila Zakry Medical botany (General) Antioxidants The demand of herbal cream has increased rapidly in the market due to the herbs’ natural content which does not pose any side effects on the human skin. In the present study, we investigated the ethyl acetate extract of Pithecellobium jiringa (P. jiringa) stem barks as antibacterial cream. The antioxidant potential of the P. jiringa extract was evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Six formulations of antibacterial creams (oil in water) were prepared and labelled as F1 to F6. All formulations were characterized by different parameters such as pH, spread ability and stability. These formulations were then investigated for their antibacterial activity against several bacteria such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K. pneumonia) and Bacillus cereus (B. cereus) by using agar disc diffusion technique. The DPPH scavenging activity showed moderate radical scavenging activity with IC50 value was 46.25 µg/mL. Among the six formulations, F6 showed the good spread ability, homogeneity, appearance and pH. The formulation did not show any phase separation and was easy to remove. The F6 formulation also showed no irritations on skin such as redness, edema, or erythema in irritancy studies. In microbiological assay, F6 formulation exhibited the largest zone inhibition against Staphylococcus aureus which was 11.52 mm at the concentration of 2.0% w/v. Therefore, the study suggests that the F6 can be safely used for the consumers that have skin irritations caused by bacteria. Universiti Teknologi MARA Cawangan Pahang 2020-03-31 Article PeerReviewed text en https://ir.uitm.edu.my/id/eprint/31114/1/31114.pdf Mat Hussin, Zurhana and Irfan Zakry, Nurin Adila Zakry (2020) Formulation and evaluation of cream from stem barks of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry. (2020) Gading Journal for Science and Technology <https://ir.uitm.edu.my/view/publication/Gading_Journal_for_Science_and_Technology.html>, 3 (1). pp. 91-99. ISSN 2637-0018 |
| spellingShingle | Medical botany (General) Antioxidants Mat Hussin, Zurhana Irfan Zakry, Nurin Adila Zakry Formulation and evaluation of cream from stem barks of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title | Formulation and evaluation of cream from stem barks
of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title_full | Formulation and evaluation of cream from stem barks
of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title_fullStr | Formulation and evaluation of cream from stem barks
of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title_full_unstemmed | Formulation and evaluation of cream from stem barks
of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title_short | Formulation and evaluation of cream from stem barks
of Pithecellobium Jiringa / Zurhana Mat Hussin and Nurin Adila Zakry Irfan Zakry |
| title_sort | formulation and evaluation of cream from stem barks
of pithecellobium jiringa / zurhana mat hussin and nurin adila zakry irfan zakry |
| topic | Medical botany (General) Antioxidants |
| url | https://ir.uitm.edu.my/id/eprint/31114/ |