Genetic polymorphism of drug metabolizing enzymes and estrogen receptor in pharmacogenetics of tamoxifen: implication for optimization of breast cancer treatment / Teh Lay Kek and Mohd Zaki Salleh

QR Code

Genetic polymorphism of drug metabolizing enzymes and estrogen receptor in pharmacogenetics of tamoxifen: implication for optimization of breast cancer treatment / Teh Lay Kek and Mohd Zaki Salleh

Introduction: Tamoxifen has been used as a hormonal therapy in breast cancer patients who are positive for estrogen receptor. The drug is metabolized by Cytochrome P450 2D6 (CYP2D6) into several metabolite. Variation in CYP2D6 activity has important therapeutic consequences and can play a significan...

Full description

Bibliographic Details
Main Authors:	Lay Kek, Teh, Salleh, Mohd Zaki
Format:	Research Reports
Language:	English
Published:	Research Management Institute (RMI) 2010
Subjects:	Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/24806/

Similar Items

Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek
by: Salleh, Mohd Zaki, et al.
Published: (2010)

Cancerpharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-Fluorouracil / Teh Lay Kek And Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Unraveling of the genetic polymorphism for ultra-rapid metabolism of phenytoin / Fazleen Haslinda Mohd Hatta , Prof Madya Dr The Lay Kek , Prof Dr Mohd Zaki Salleh
by: Mohd Hatta, Fazleen Haslinda, et al.
Published: (2010)

Cancer pharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-fluorouracil / Prof Madya Dr Teh Lay Kek and Prof Dr Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Genetic polymorphism of CYP2C9 in patients on warfarin therapy and the clinical relevance / Teh Lay Kek... [et al.]
by: Teh, Lay Kek, et al.
Published: (2007)

Transgenerational epigenetics in substance abuse: exploring the inheritable DNA methylation underlying the agressive behaviour and altered stress response. / Professor Dr Teh Lay Kek, Professor Dr Mohd Zaki Salleh and Dr. Richard Muhammad Johari James
by: Lay Kek, Teh, et al.
Published: (2016)

The role of pharmacogenetic variation in metoprolol CYP2D6 genotypes polymorphism
by: Wan Sulaiman, Wan Mohd. Azizi, et al.
Published: (2011)

Vulnerability assessment and blue carbon potential of two mangrove sites in Malaysia / Teh Lay Hoon
by: Teh, Lay Hoon
Published: (2015)

Polymorphisms in Estrogen Receptor-Α and -Β Genes and Their Correlations with Risk Factors in Iranian Breast Cancer Patients
by: Abbasi, Sakineh
Published: (2009)

Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
by: Mohamed, Nor Izwani
Published: (2017)

Multimodal assessment of estrogen receptor mRNA profiles to quantify estrogen pathway activity in breast tumors
by: Muthukaruppan, Anita, et al.
Published: (2017)

Kek pop Masitah
by: Ishak, Mahani
Published: (2014)

Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development
by: Akkari, Patrick, et al.
Published: (2009)

Estrogen receptor-α gene codon 10 (T392C) polymorphism in Iranian women with breast cancer: a case study
by: Abbasi, Sakineh, et al.
Published: (2009)

Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
by: Rehman, Asia
Published: (2006)

Pulsed laser deposition of aluminium-doped zinc oxide films for optoelectronics application / Reeson Kek
by: Reeson , Kek
Published: (2017)

Role of RhoGDIα on migration and invasion of estrogen receptor positive MCF7 and estrogen receptor negative MDA-MB-231 breast cancer cells
by: Hooshmand, Somayeh
Published: (2014)

Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes
by: Muhammad, Sani Ismaila, et al.
Published: (2013)

Dikejutkan 'kek hari jadi'
Published: (2010)

Elevated expression of CD151 gene in estrogen receptor and progesterone receptor positive breast carcinoma
by: Ivyna Bong PN,, et al.
Published: (2011)

Pharmacogenetics, pharmacogenomics and airway disease
by: Hall, Ian P.
Published: (2002)

Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study
by: Abbasi, Sakineh, et al.
Published: (2009)

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
by: Bannur, Zakaria, et al.
Published: (2014)

A comparison study of leisure activities between the arts and sciences students in University of Malaya / Chin Kek Way
by: Chin , Kek Way
Published: (1985)

Genetic Polymorphism of CYP2D6 and MDR1 in breast cancer patients treated with tamoxifen
by: Mohamad, NI, et al.
Published: (2010)

Transcriptomic profiling and validation of early onset estrogen receptor-positive breast cancer patients
by: Siddig, Alaa Abdelaziz Mahmoud
Published: (2023)

Pharmacogenetics in cardiovascular disorders: An update on the principal drugs
by: Predazzi, I., et al.
Published: (2013)

Pharmacogenetics of beta adrenergic blockers: their clinical significance
by: Elsayed, Tarek Mohamed Ali
Published: (2009)

The outcome of breast cancer based on the expression of c-erbb2 , estrogen receptor and progesterone receptor: kelantan experience 2002-2004
by: Mohamed, Moharzudi
Published: (2010)

The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1
by: Teh, L. K., et al.
Published: (2011)

Long term use of tamoxifen
by: Al-Salami, Hani, et al.
Published: (2012)

Immunohistochemical expression of estrogen receptor alpha in benign prostatic hyperplasia and prostatic carcinoma in Iraqi patients
by: Mohammed, Wafaa R., et al.
Published: (2018)

Propaganda dalam darurat pertama di Malaysia, 1948-1960 / Mohd Zaki Mohd Salleh.
by: Mohd Salleh, Mohd Zaki
Published: (2003)

UNIMAS attempts to make biggest, thickest kek lapis
by: Sarawak Tribune
Published: (2012)

A Review on Development of Kek Lapis Sarawak's Machine
by: Mohamad Syamim, Hamsawi, et al.
Published: (2016)

Determinants of savings in Malaysia / Tan Lay Keat
by: Tan, Lay Keat
Published: (2004)

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia
by: Ware, James S., et al.
Published: (2017)

Modulation of cytochrome P450s by strobilanthes crispus anticancer sub-fraction and its potential interaction with tamoxifen metabolism
by: Fen, Yong Ya
Published: (2020)

Molecular docking analysis of 6-paradol, Zingerone and Zerumbone against human estrogen receptor alpha (ERɑ)
by: Sharif, Mohd. Faez, et al.
Published: (2018)

Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
by: Aung, Sanda, et al.
Published: (2013)