Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2017
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19903/ |
| _version_ | 1848804882849464320 |
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| author | Mohamed, Nor Izwani |
| author_facet | Mohamed, Nor Izwani |
| author_sort | Mohamed, Nor Izwani |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges to effective tamoxifen therapy include drug resistance, and adverse events. Thus, this study aims to investigate the impact of pharmacogenomics and metabolomics in monitoring the efficacy of tamoxifen treatment in BRCA patients. A total of 95 tamoxifen-treated patients, and 11 untreated breast cancer patients from three major Malaysian ethnic groups (Malay, Chinese and Indian) were recruited. However, only 84 tamoxifen-treated patients with completed clinical data were included for clinical association analysis. |
| first_indexed | 2025-11-14T22:02:12Z |
| format | Book Section |
| id | uitm-19903 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T22:02:12Z |
| publishDate | 2017 |
| publisher | Institute of Graduate Studies, UiTM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-199032018-06-08T03:55:10Z https://ir.uitm.edu.my/id/eprint/19903/ Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed Mohamed, Nor Izwani Malaysia Research. Experimentation Tamoxifen has been widely used as the standard adjuvant therapy for breast cancer patients with oestrogen receptor-positive status, especially in the highrisk pre- and postmenopausal women. However, 30 to 50% of ER-positive breast cancer patients do not respond to tamoxifen therapy. Major challenges to effective tamoxifen therapy include drug resistance, and adverse events. Thus, this study aims to investigate the impact of pharmacogenomics and metabolomics in monitoring the efficacy of tamoxifen treatment in BRCA patients. A total of 95 tamoxifen-treated patients, and 11 untreated breast cancer patients from three major Malaysian ethnic groups (Malay, Chinese and Indian) were recruited. However, only 84 tamoxifen-treated patients with completed clinical data were included for clinical association analysis. Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19903/1/ABS_NOR%20IZWANI%20MOHAMED%20TDRA%20VOL%2012%20IGS%2017.pdf Mohamed, Nor Izwani (2017) Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed. (2017) In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Research. Experimentation Mohamed, Nor Izwani Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title | Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title_full | Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title_fullStr | Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title_full_unstemmed | Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title_short | Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed |
| title_sort | interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / nor izwani mohamed |
| topic | Malaysia Research. Experimentation |
| url | https://ir.uitm.edu.my/id/eprint/19903/ |