Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi
Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced thro...
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| Format: | Book Section |
| Language: | English |
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Institute of Graduate Studies, UiTM
2017
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| Online Access: | https://ir.uitm.edu.my/id/eprint/19900/ |
| _version_ | 1848804881993826304 |
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| author | Md Azmi, Nik Salwani |
| author_facet | Md Azmi, Nik Salwani |
| author_sort | Md Azmi, Nik Salwani |
| building | UiTM Institutional Repository |
| collection | Online Access |
| description | Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced through crystallization process. However, even slight changes in the crystallization condition can drastically alter crystals properties. Control of the process in order to control the physicochemical properties (solubility, morphology, polymorphism) is crucial to produce the right type of crystal. To overcome this problem, electric potential was applied with the intention to control the process. Hence it has become the main objective of this study to determine the effect of electric potential on solubility and mestastable zone width (MSZW) of L-isoleucine crystallization. Solubility of L-isoleucine experiment was conducted using three different methods; (1) Solubility Method A: Gravimetric method, (2) Solubility Method B: Isothermal dissolution and (3) Solubility Method C: Dissolution with controlled heating rate, while polythermal and isothermal method was adopted for the crystallization process. The results showed that all three methods gave significant difference in solubility data. |
| first_indexed | 2025-11-14T22:02:11Z |
| format | Book Section |
| id | uitm-19900 |
| institution | Universiti Teknologi MARA |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T22:02:11Z |
| publishDate | 2017 |
| publisher | Institute of Graduate Studies, UiTM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uitm-199002018-06-08T03:50:31Z https://ir.uitm.edu.my/id/eprint/19900/ Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi Md Azmi, Nik Salwani Malaysia Crystallization is a major technological process for particle formations. It is important and widely used in the production of pharmaceutical drugs since most drugs particles are produced in crystalline form. L-isoleucine is one of the drugs that exist in crystalline form and it can be produced through crystallization process. However, even slight changes in the crystallization condition can drastically alter crystals properties. Control of the process in order to control the physicochemical properties (solubility, morphology, polymorphism) is crucial to produce the right type of crystal. To overcome this problem, electric potential was applied with the intention to control the process. Hence it has become the main objective of this study to determine the effect of electric potential on solubility and mestastable zone width (MSZW) of L-isoleucine crystallization. Solubility of L-isoleucine experiment was conducted using three different methods; (1) Solubility Method A: Gravimetric method, (2) Solubility Method B: Isothermal dissolution and (3) Solubility Method C: Dissolution with controlled heating rate, while polythermal and isothermal method was adopted for the crystallization process. The results showed that all three methods gave significant difference in solubility data. Institute of Graduate Studies, UiTM 2017 Book Section PeerReviewed text en https://ir.uitm.edu.my/id/eprint/19900/2/ABS_NIK%20SALWANI%20MD%20AZMI%20TDRA%20VOL%2012%20IGS%2017.pdf Md Azmi, Nik Salwani (2017) Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi. (2017) In: The Doctoral Research Abstracts. IGS Biannual Publication, 12 (12). Institute of Graduate Studies, UiTM, Shah Alam. |
| spellingShingle | Malaysia Md Azmi, Nik Salwani Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title | Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title_full | Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title_fullStr | Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title_full_unstemmed | Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title_short | Electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / Nik Salwani Md Azmi |
| title_sort | electric potential assisted crystallization of lisoleucine in aqueous phase: experimental and computational modelling approach / nik salwani md azmi |
| topic | Malaysia |
| url | https://ir.uitm.edu.my/id/eprint/19900/ |